, Volume 110, Issue 1, pp 97-99
Date: 23 Jun 2005

Spindle cell oncocytoma of the adenohypophysis: report of two cases

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Spindle cell oncocytoma of the adenohypophysis is a recently described, spindle and granular cell, S-100 protein-positive, GFAP-negative, neuroendocrine marker-negative, mitochondria-rich neoplasm of uncertain histogenesis that can clinically and radiologically mimic pituitary adenoma. We present two cases of this entity to extend understanding of this unusual tumor.

The first case was a 26-year-old man who presented with a 6-month history of progressive headache, blurred vision in the right eye, nausea, vomiting and impotence. Magnetic resonance imaging (MRI) revealed a rounded, 1.5- to 2-cm homogeneously enhancing mass in the pituitary region, which involved the right cavernous sinus, impinged on the temporal lobe and expanded the sella. At transsphenoidal exploration, the mass was firm and difficult to dissect. Following this procedure, visual acuity in the right eye worsened and he underwent a right pterional craniotomy with subtotal resection of the tumor, with residual tumor remai ...