Acta Neuropathologica

, Volume 109, Issue 6, pp 583–588

Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease

Authors

    • Department of NeurologyKanto Central Hospital
  • Takeshi Amino
    • Department of NeurologyKanto Central Hospital
  • Yoshinori Itoh
    • Department of Internal MedicineYokufukai Geriatric Hospital
  • Atsushi Takahashi
    • Organ and Function Pathology DivisionYokufukai Geriatric Hospital
  • Tohru Kojo
    • Department of NeuropathologyTokyo Metropolitan Institute for Neuroscience
  • Toshiki Uchihara
    • Department of NeuropathologyTokyo Metropolitan Institute for Neuroscience
  • Kuniaki Tsuchiya
    • Department of Laboratory Medicine and PathologyTokyo Metropolitan Matsuzawa Hospital
  • Fumiaki Mori
    • Department of Neuropathology, Institute of Brain ScienceHirosaki University School of Medicine
  • Koichi Wakabayashi
    • Department of Neuropathology, Institute of Brain ScienceHirosaki University School of Medicine
  • Hitoshi Takahashi
    • Department of Pathology, Brain Research Institute University of Niigata
Regular Paper

DOI: 10.1007/s00401-005-0995-7

Cite this article as:
Orimo, S., Amino, T., Itoh, Y. et al. Acta Neuropathol (2005) 109: 583. doi:10.1007/s00401-005-0995-7

Abstract

Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [123I]MIBG myocardial scintigraphy has been reported in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). We hypothesized that cardiac sympathetic denervation might account for the pathomechanism. To elucidate the extent, frequency and pattern of cardiac sympathetic nerve involvement in Lewy body disease and related neurodegenerative disorders, we immunohistochemically examined heart tissues from patients with PD (n=11), DLB (n=7), DLB with Alzheimer’s disease (DLB/AD; n=4), multiple system atrophy (MSA; n=8), progressive supranuclear palsy (PSP; n=5), pure AD (n=10) and control subjects (n=5) together with sympathetic ganglia from patients with PD (n=5) and control subjects (n=4), using an antibody against tyrosine hydroxylase (TH). TH-immunoreactive nerve fibers in the hearts had almost entirely disappeared in nearly all the patients with PD, DLB and DLB/AD, whereas they were well preserved in all the patients with PSP and pure AD as well as in all except for one patient with MSA. In PD, neurons in the sympathetic ganglia were preserved in all except for one patient. Decreased cardiac uptake of MIBG in Lewy body disease reflects actual cardiac sympathetic denervation, which precedes the neuronal loss in the sympathetic ganglia.

Keywords

meta-iodobenzylguanidineCardiac sympathetic denervationSympathetic gangliaParkinson’s diseaseDementia with Lewy bodies

Copyright information

© Springer-Verlag 2005