Acta Neuropathologica

, Volume 111, Issue 2, pp 115–125

The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies

  • Huseyin A. Sahin
  • Murat Emre
  • Iryna Ziabreva
  • Elaine Perry
  • Bulent Celasun
  • Robert Perry
Original Paper

DOI: 10.1007/s00401-005-0003-2

Cite this article as:
Sahin, H.A., Emre, M., Ziabreva, I. et al. Acta Neuropathol (2006) 111: 115. doi:10.1007/s00401-005-0003-2

Abstract

We studied the distribution pattern of pathology and cholinergic deficits in the subnuclei of the amygdaloid complex (AC) in five patients with Alzheimer's disease (AD), eight with dementia with Lewy bodies (DLB) and five normal controls. In controls, the basal nucleus contained the highest choline acetyltransferase activity; the activity in the lateral and central nuclei and those in the cortical, medial and accessory basal nuclei were comparable. In AD, there was a significant decrease in choline acetyltransferase activity in the accessory basal and lateral nuclei, in DLB a significant decrease was observed in the accessory basal, lateral and cortical nuclei. Compared to controls the hyperphosphorylated tau-pathology burden was significantly higher in the basal, central and medial nuclei in AD and in the central, cortical, lateral and medial nuclei in DLB. The amyloid plaque burden was significantly higher in the accessory basal, basal, lateral and cortical nuclei in AD and in all nuclei in DLB. The α-synuclein burden was significantly higher in all nuclei in both AD and DLB. Compared to AD α-synuclein burden was higher in all nuclei in DLB. There were no correlations between the distribution pattern of hyperphosphorylated tau-pathology, amyloid plaques and α-synuclein-positive structures, and choline acetyltransferase activity, except the lateral nucleus in DLB. In conclusion we found no relationship between the pattern of cholinergic deficits and the distribution pattern of lesions in the AC of patients with AD or DLB. Cholinergic deficits were more prominent in the nuclei of basolateral (BL) group in AD, whereas the nuclei of both BL and corticomedial groups were involved in DLB, which may be due to the involvement of both basal forebrain and brainstem cholinergic nuclei in the latter.

Keywords

AmygdalaCholinergic systemAlzheimer diseaseDementia with Lewy bodies

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Huseyin A. Sahin
    • 1
  • Murat Emre
    • 2
  • Iryna Ziabreva
    • 3
  • Elaine Perry
    • 3
  • Bulent Celasun
    • 4
  • Robert Perry
    • 5
  1. 1.Department of NeurologyOndokuz Mayis University, Faculty of MedicineSamsunTurkey
  2. 2.Department of NeurologyUniversity of Istanbul, Istanbul Faculty of Medicine, Behavioral Neurology and Movement Disorders UnitIstanbulTurkey
  3. 3.Institute for Ageing and Health, MRC BuildingNewcastle General HospitalNewcastle upon TyneUK
  4. 4.Department of PathologyGulhane Military Medical Academy and School of MedicineAnkaraTurkey
  5. 5.Department of NeuropathologyNewcastle General HospitalNewcastle upon TyneUK