Acta Neuropathologica

, Volume 110, Issue 2, pp 113–119

Expression pattern of NOGO-A protein in the human nervous system

  • A. Buss
  • B. Sellhaus
  • A. Wolmsley
  • J. Noth
  • M. E. Schwab
  • G. A. Brook
Regular Paper

DOI: 10.1007/s00401-004-0942-z

Cite this article as:
Buss, A., Sellhaus, B., Wolmsley, A. et al. Acta Neuropathol (2005) 110: 113. doi:10.1007/s00401-004-0942-z

Abstract

The distribution pattern of NOGO-A protein, an important axon growth inhibitory molecule and member of the reticulon family, has been investigated in the adult human brain, spinal cord, retina and dorsal root ganglia. Intense NOGO-A immunoreactivity was detected in oligodendroglial cell bodies and their myelin sheaths in nerve fibre tracts of the central nervous system. Furthermore, numerous populations of neurons in the brain and spinal cord expressed NOGO-A to a variable extent in their cell bodies and neurites, suggesting additional, as-yet-unknown, functions of this protein.

Keywords

RegenerationNOGOHumanOligodendrocyteMyelin

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • A. Buss
    • 1
  • B. Sellhaus
    • 2
  • A. Wolmsley
    • 3
  • J. Noth
    • 1
  • M. E. Schwab
    • 4
  • G. A. Brook
    • 1
  1. 1.Department of NeurologyAachen University Medical SchoolAachenGermany
  2. 2.Department of NeuropathologyAachen University Medical SchoolAachenGermany
  3. 3.Nervous System ResearchNovartis PharmaBaselSwitzerland
  4. 4.Brain Research Institute, University of Zurich, and Department of BiologyETH ZurichZurichSwitzerland