Acta Neuropathologica

, Volume 106, Issue 3, pp 251–260

4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy

Authors

  • Omi Katsuse
    • Department of PsychiatryYokohama City University School of Medicine
    • Department of PsychiatryYokohama City University School of Medicine
  • Tetsuaki Arai
    • Department of PsychogeriatricsTokyo Institute of Psychiatry
  • Haruhiko Akiyama
    • Department of PsychogeriatricsTokyo Institute of Psychiatry
  • Takashi Togo
    • Department of PsychiatryYokohama City University School of Medicine
  • Hirotake Uchikado
    • Department of PsychiatryYokohama City University School of Medicine
  • Masanori Kato
    • Soga Hospital
  • Rohan de Silva
    • Reta Lila Weston Institute of Neurological StudiesUniversity College London
  • Andrew Lees
    • Reta Lila Weston Institute of Neurological StudiesUniversity College London
  • Kenji Kosaka
    • Department of PsychiatryYokohama City University School of Medicine
Regular Paper

DOI: 10.1007/s00401-003-0728-8

Cite this article as:
Katsuse, O., Iseki, E., Arai, T. et al. Acta Neuropathol (2003) 106: 251. doi:10.1007/s00401-003-0728-8

Abstract

We report a 67-year-old man with 4-repeat (4R) tauopathy sharing both features of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Although CBD and PSP have a common pathological feature that 4R tau accumulates in neurons and glia, recent pathological studies have confirmed differences between the two disorders. Clinical features of the present case were asymmetrical apraxia, parkinsonism, memory disturbance, disorientation and left limb myoclonus with a 5-year history. Pathological features were the widespread occurrence of 4R tau-positive structures including pre-tangles, neurofibrillary tangles, astrocytic plaques, tufted astrocytes, coiled bodies and argyrophilic threads. Biochemically, immunoblotting of insoluble tau demonstrated the low molecular fragments of 37 kDa and 33 kDa observed in typical CBD and PSP, respectively, in addition to the presence of 4R tau isoforms. The present case shared tau-related pathological and biochemical features of CBD and PSP. These findings support that CBD and PSP are closely associated disorders having a pathogenesis common to 4R tauopathy.

Keywords

4-repeat tauopathyCorticobasal degenerationProgressive supranuclear palsyAstrocytic plaqueTufted astrocyte

Copyright information

© Springer-Verlag 2003