Acta Neuropathologica

, Volume 106, Issue 3, pp 251–260

4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy

  • Omi Katsuse
  • Eizo Iseki
  • Tetsuaki Arai
  • Haruhiko Akiyama
  • Takashi Togo
  • Hirotake Uchikado
  • Masanori Kato
  • Rohan de Silva
  • Andrew Lees
  • Kenji Kosaka
Regular Paper

DOI: 10.1007/s00401-003-0728-8

Cite this article as:
Katsuse, O., Iseki, E., Arai, T. et al. Acta Neuropathol (2003) 106: 251. doi:10.1007/s00401-003-0728-8

Abstract

We report a 67-year-old man with 4-repeat (4R) tauopathy sharing both features of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Although CBD and PSP have a common pathological feature that 4R tau accumulates in neurons and glia, recent pathological studies have confirmed differences between the two disorders. Clinical features of the present case were asymmetrical apraxia, parkinsonism, memory disturbance, disorientation and left limb myoclonus with a 5-year history. Pathological features were the widespread occurrence of 4R tau-positive structures including pre-tangles, neurofibrillary tangles, astrocytic plaques, tufted astrocytes, coiled bodies and argyrophilic threads. Biochemically, immunoblotting of insoluble tau demonstrated the low molecular fragments of 37 kDa and 33 kDa observed in typical CBD and PSP, respectively, in addition to the presence of 4R tau isoforms. The present case shared tau-related pathological and biochemical features of CBD and PSP. These findings support that CBD and PSP are closely associated disorders having a pathogenesis common to 4R tauopathy.

Keywords

4-repeat tauopathyCorticobasal degenerationProgressive supranuclear palsyAstrocytic plaqueTufted astrocyte

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Omi Katsuse
    • 1
  • Eizo Iseki
    • 1
  • Tetsuaki Arai
    • 2
  • Haruhiko Akiyama
    • 2
  • Takashi Togo
    • 1
  • Hirotake Uchikado
    • 1
  • Masanori Kato
    • 3
  • Rohan de Silva
    • 4
  • Andrew Lees
    • 4
  • Kenji Kosaka
    • 1
  1. 1.Department of PsychiatryYokohama City University School of MedicineYokohamaJapan
  2. 2.Department of PsychogeriatricsTokyo Institute of PsychiatryTokyoJapan
  3. 3.Soga HospitalOdawaraJapan
  4. 4.Reta Lila Weston Institute of Neurological StudiesUniversity College LondonLondonUK