Acta Neuropathologica

, Volume 106, Issue 2, pp 121–124

Enhanced expression of aquaporin 4 in human brain with infarction

  • Kazuko Aoki
  • Toshiki Uchihara
  • Kuniaki Tsuchiya
  • Ayako Nakamura
  • Kenji Ikeda
  • Yoshihiro Wakayama
Regular Paper

DOI: 10.1007/s00401-003-0709-y

Cite this article as:
Aoki, K., Uchihara, T., Tsuchiya, K. et al. Acta Neuropathol (2003) 106: 121. doi:10.1007/s00401-003-0709-y

Abstract

A series of human brains with cerebral infarction obtained at autopsy were investigated to clarify the possible contribution of aquaporin 4 (AQP4) to the development of brain edema. Cellular localization of AQP4 and its relation to ischemic foci were examined with double-labeling immunohistochemistry. AQP4 immunoreactivity (IR) was more intense at the periphery of ischemic foci than at their center. Double-labeling study demonstrated that AQP4 IR was restricted to astrocytes and was localized to their entire processes, including their end feet facing the outer surface of capillaries. Moreover, AQP4 IR, detectable in the subpial and subependymal zone in the normal condition, was more intense in the vicinity of ischemic foci. Accumulation of AQP4 IR may reflect its participation in the development of brain edema in human brains by playing a role in the transport of water not only through blood vessel walls but also through pial and ependymal surface of the brain.

Keywords

Aquaporin 4IschemiaGliaBrain edemaOsmotic regulation

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Kazuko Aoki
    • 1
    • 2
    • 3
  • Toshiki Uchihara
    • 1
  • Kuniaki Tsuchiya
    • 4
  • Ayako Nakamura
    • 1
  • Kenji Ikeda
    • 5
  • Yoshihiro Wakayama
    • 2
  1. 1.Department of NeuropathologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  2. 2.Department of NeurologyShowa University Fujigaoka HospitalYokohamaJapan
  3. 3.Department of NeurologyMetropolitan Fuchu Medical Center for Severe Motor and Intellectual DisabilitiesTokyoJapan
  4. 4.Department of Laboratory Medicine and PathologyTokyo Metropolitan Matsuzawa HospitalTokyoJapan
  5. 5.Department of PsychogeriatricsTokyo Institute of PsychiatryTokyoJapan