Colloid and Polymer Science

, Volume 291, Issue 1, pp 157–165

Drug release system of ibuprofen in PCL-microspheres

Authors

    • Department of Chemical EngineeringPolytechnic University of Catalonia
  • V. Acuña
    • Department of Chemical EngineeringPolytechnic University of Catalonia
  • M. Martí
    • Institut de Química Avançada de Catalunya, (IQAC-CSIC)
  • M. J. Lis
    • INTEXTER-UPC. Polquitex Research Group
Original Contribution

DOI: 10.1007/s00396-012-2768-x

Cite this article as:
Carreras, N., Acuña, V., Martí, M. et al. Colloid Polym Sci (2013) 291: 157. doi:10.1007/s00396-012-2768-x

Abstract

Today, the technology of microencapsulation of active principles is on top of biomedical advances, because through it we can solve many of the problems caused by current methods of taking medication. Active principle microencapsulation not only solves the problems of drug intake but also controls its dosage. In this study was carried out the development of a protocol for the microencapsulation of ibuprofen by solvent evaporation method. A subsequent application of those microencapsulates to biofunctional textile substrates (cotton, polyamide, acrylic, and polyester) using a finishing process, and finally a study of the release of active principle in two different media (deionized water and physiological serum) has been carried out using samples of the treated fabrics that were submerged into a thermostatized vessel at semi-infinite bath conditions. The determination of active principles released to the bath was determined by a UV spectrophotometer. These experimental results have been analyzed and evaluated, and have therefore allowed to define a controlled drug release system by Fickian diffusion in different media.

Keywords

MicrocapsulesBiofunctional textile substratesDrug releaseIbuprofen

Copyright information

© Springer-Verlag 2012