Original Contribution

Colloid and Polymer Science

, Volume 291, Issue 1, pp 157-165

First online:

Drug release system of ibuprofen in PCL-microspheres

  • N. CarrerasAffiliated withDepartment of Chemical Engineering, Polytechnic University of Catalonia Email author 
  • , V. AcuñaAffiliated withDepartment of Chemical Engineering, Polytechnic University of Catalonia
  • , M. MartíAffiliated withInstitut de Química Avançada de Catalunya, (IQAC-CSIC)
  • , M. J. LisAffiliated withINTEXTER-UPC. Polquitex Research Group

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Today, the technology of microencapsulation of active principles is on top of biomedical advances, because through it we can solve many of the problems caused by current methods of taking medication. Active principle microencapsulation not only solves the problems of drug intake but also controls its dosage. In this study was carried out the development of a protocol for the microencapsulation of ibuprofen by solvent evaporation method. A subsequent application of those microencapsulates to biofunctional textile substrates (cotton, polyamide, acrylic, and polyester) using a finishing process, and finally a study of the release of active principle in two different media (deionized water and physiological serum) has been carried out using samples of the treated fabrics that were submerged into a thermostatized vessel at semi-infinite bath conditions. The determination of active principles released to the bath was determined by a UV spectrophotometer. These experimental results have been analyzed and evaluated, and have therefore allowed to define a controlled drug release system by Fickian diffusion in different media.


Microcapsules Biofunctional textile substrates Drug release Ibuprofen