Original Contribution

Colloid and Polymer Science

, Volume 286, Issue 5, pp 563-569

First online:

Size-controlled synthesis of monodisperse core/shell nanogels

  • William H. BlackburnAffiliated withSchool of Chemistry and Biochemistry & Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
  • , L. Andrew LyonAffiliated withSchool of Chemistry and Biochemistry & Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology Email author 

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Abstract

Small, monodisperse nanogels (∼50-nm radius) were synthesized by free-radical precipitation polymerization and were characterized using a suite of light scattering and chromatography methods. Nanogels were synthesized with either N-isopropylacrylamide or N-isopropylmethacrylamide as the main monomer, with acrylic acid or 4-acrylamidofluorescein as a comonomer and N,N′-methylenebis(acrylamide) as a cross-linker. By varying the surfactant and initiator concentrations, particle size was controlled while maintaining excellent monodispersity. An amine-containing shell was added to these core particles to facilitate subsequent bioconjugation. Successful conjugation of folic acid to the particles was demonstrated as an example of how such materials might be employed in a targeted drug delivery system.

Keywords

Nanogels Synthesis Bioconjugation Monodispersity Core/shell