Colloid and Polymer Science

, Volume 286, Issue 5, pp 563–569

Size-controlled synthesis of monodisperse core/shell nanogels

Original Contribution

DOI: 10.1007/s00396-007-1805-7

Cite this article as:
Blackburn, W.H. & Lyon, L.A. Colloid Polym Sci (2008) 286: 563. doi:10.1007/s00396-007-1805-7

Abstract

Small, monodisperse nanogels (∼50-nm radius) were synthesized by free-radical precipitation polymerization and were characterized using a suite of light scattering and chromatography methods. Nanogels were synthesized with either N-isopropylacrylamide or N-isopropylmethacrylamide as the main monomer, with acrylic acid or 4-acrylamidofluorescein as a comonomer and N,N′-methylenebis(acrylamide) as a cross-linker. By varying the surfactant and initiator concentrations, particle size was controlled while maintaining excellent monodispersity. An amine-containing shell was added to these core particles to facilitate subsequent bioconjugation. Successful conjugation of folic acid to the particles was demonstrated as an example of how such materials might be employed in a targeted drug delivery system.

Keywords

NanogelsSynthesisBioconjugationMonodispersityCore/shell

Abbreviations

NIPAm

N-isopropylacrylamide

LCST

lower critical solution temperature

NIPMAm

N-isopropylmethacrylamide

AAc

acrylic acid

EPR

enhanced permeability and retention

RES

reticuloendothelial system

APS

ammonium persulfate

SDS

sodium dodecyl sulfate

BIS

N,N′-methylenebis(acrylamide)

APMA

N-(3-aminopropyl) methacrylamide hydrochloride

EDC

1-ethyl-3-methyl-(3-dimethylaminopropyl)carbodiimide

DMSO

dimethyl sulfoxide

AFA

4-acrylamidofluorescein

MALLS

multi-angle laser light scattering

AFFF

asymmetric field flow fractionation

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.School of Chemistry and Biochemistry & Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaUSA