Colloid and Polymer Science

, Volume 283, Issue 11, pp 1246–1252

Tri-component diblock copolymers of poly(ethylene glycol)–poly(ε-caprolactone-co-lactide): synthesis, characterization and loading camptothecin

  • Yan Zhang
  • Changchun Wang
  • Wuli Yang
  • Bin Shi
  • Shoukuan Fu
Short communication Polymer

DOI: 10.1007/s00396-005-1306-5

Cite this article as:
Zhang, Y., Wang, C., Yang, W. et al. Colloid Polym Sci (2005) 283: 1246. doi:10.1007/s00396-005-1306-5

Abstract

Biodegradable tri-component diblock copolymer was synthesized by bulk copolymerization of ε-caprolactone (CL) and D, L-lactide (LA) in the presence of methoxy poly(ethylene glycol) (MePEG), using stannous octoate as catalyst. Their chemical structure and physical properties were investigated by GPC, NMR, DSC, TGAand XRD. The increase of CL/LA ratio in the diblock copolymer leads to lower Tg, higher decomposition temperature and crystallinity. Nanoparticles formulated from MePEG–poly(CL-co-LA) (PCAE) possess spherical structure, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The DLS results indicate that the particle size increased with the increase of CL/LA ratio and the hydrophobic fragment length in the copolymer. The drug encapsulation efficiency and the drug release behavior in vitro conditions of camptothecin were measured by high performance liquid chromatography (HPLC). The encapsulation efficiency can be achieved as high as 84.4% and the release behavior can be made well-controlled. MePEG–poly(CL-co-LA) nanoparticles might have a great potential as carriers for hydrophobic drugs.

Keywords

Methoxy poly(ethylene glycol)–poly(ε-caprolactone-co-lactide)Diblock copolymerNanoparticlesCamptothecinDrug carrier

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Yan Zhang
    • 1
    • 2
  • Changchun Wang
    • 1
  • Wuli Yang
    • 1
  • Bin Shi
    • 3
  • Shoukuan Fu
    • 1
  1. 1.Department of macromolecular Science of Fudan University and the Key Laboratory of Molecular Engineering of PolymersMinistry of EducationShanghaiChina
  2. 2.Modern Experiment Technology CenterAnhui UniversityHefeiChina
  3. 3.School of Pharmacy of Fudan UniversityShanghaiChina