, Volume 104, Issue 2, pp 111-112
Date: 04 Mar 2009

The regulation and control of mitochondrial homeostasis in changing cardiac tolerance to ischemia-reperfusion injury: a focused issue

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The resurgence of investigation into mitochondrial biology stems, in part, from the realization that the regulation of mitochondrial content, turnover, and function to maintain diverse homeostatic demands are driven by exquisite biochemical and molecular controls. In the last decade the regulatory programs governing mitochondrial biogenesis [1], dynamics [2], responses to stressors, and post-translational regulatory control programs [3] have become more clearly defined. In the heart, this ‘fine-tuning’ of mitochondrial biology is proposed to modulate cardiac susceptibility to oxidative stress, ischemia-reperfusion injury, metabolic syndromes, and heart failure [47]. The National Heart Lung and Blood Institute, together with the Office of Rare Diseases of the National Institutes of Health and the Society of Heart and Vascular Metabolism funded an international conference held in Bethesda, MD, USA, to review these recent advances. In this focused issue of Basic Research in Cardiology, t