Basic Research in Cardiology

, Volume 104, Issue 2, pp 181–188

The mitochondrial permeability transition pore and ischemia-reperfusion injury

Review

DOI: 10.1007/s00395-009-0004-8

Cite this article as:
Baines, C.P. Basic Res Cardiol (2009) 104: 181. doi:10.1007/s00395-009-0004-8

Abstract

Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) pore, a large, non-specific channel that spans the inner mitochondrial membrane, is known to mediate the lethal permeability changes that initiate mitochondrial-driven cardiomyocyte death. The purpose of this review is to focus on the role of the MPT pore in ischemia-reperfusion injury, the mechanisms involved, and, in particular, what we do and do not know regarding the pore’s molecular composition.

Keywords

Ischemia-reperfusionMitochondrial permeability transitionVoltage-dependent anion channelAdenine nucleotide translocaseCyclophilin-DBcl-2 proteins

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Biomedical Sciences, Dalton Cardiovascular Research CenterUniversity of Missouri-ColumbiaColumbiaUSA