REVIEW

Basic Research in Cardiology

, Volume 104, Issue 1, pp 22-32

Innate immunity and myocardial adaptation to ischemia

  • Hanne Støre ValeurAffiliated withInstitute of Basic Medical Sciences (IMB), Dept. of Physiology, University of Oslo
  • , Guro ValenAffiliated withInstitute of Basic Medical Sciences (IMB), Dept. of Physiology, University of Oslo Email author 

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Abstract

Myocardial adaptation to ischemia in the form of ischemic preconditioning is clinically attractive, but not directly usable until molecular mimics are discovered. A growing body of evidence indicates that events underlying myocardial adaptation to ischemia may either involve, or be parallel to, signaling of the innate immune response. Preconditioning-like protection of the heart can be evoked through giving cytokines or fragments of bacterial walls. A possible role for cytokines, toll-like receptors, and nuclear factor kappa B for evoking ischemic preconditioning are discussed. Through stimulating innate immunity, there is potential to bring preconditioning into the clinics in a reasonable time frame. The possibility that the underlying protective response may involve adaptive immunity through danger signaling is briefly reviewed.

Keywords

preconditioning cytokines toll-like receptors nuclear factor kappa B adaptive immunity