Basic Research in Cardiology

, Volume 104, Issue 1, pp 22–32

Innate immunity and myocardial adaptation to ischemia

REVIEW

DOI: 10.1007/s00395-008-0756-6

Cite this article as:
Valeur, H.S. & Valen, G. Basic Res Cardiol (2009) 104: 22. doi:10.1007/s00395-008-0756-6

Abstract

Myocardial adaptation to ischemia in the form of ischemic preconditioning is clinically attractive, but not directly usable until molecular mimics are discovered. A growing body of evidence indicates that events underlying myocardial adaptation to ischemia may either involve, or be parallel to, signaling of the innate immune response. Preconditioning-like protection of the heart can be evoked through giving cytokines or fragments of bacterial walls. A possible role for cytokines, toll-like receptors, and nuclear factor kappa B for evoking ischemic preconditioning are discussed. Through stimulating innate immunity, there is potential to bring preconditioning into the clinics in a reasonable time frame. The possibility that the underlying protective response may involve adaptive immunity through danger signaling is briefly reviewed.

Keywords

preconditioningcytokinestoll-like receptorsnuclear factor kappa Badaptive immunity

Copyright information

© Springer 2008

Authors and Affiliations

  1. 1.Institute of Basic Medical Sciences (IMB), Dept. of PhysiologyUniversity of OsloOsloNorway