European Journal of Nutrition

, Volume 52, Issue 3, pp 859–867

Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant

  • Nicola Principi
  • Sonia Bianchini
  • Elena Baggi
  • Susanna Esposito
Review

DOI: 10.1007/s00394-012-0476-4

Cite this article as:
Principi, N., Bianchini, S., Baggi, E. et al. Eur J Nutr (2013) 52: 859. doi:10.1007/s00394-012-0476-4

Abstract

Background

It has recently been demonstrated that vitamin D (VD) deficiency during pregnancy and lactation can give rise to problems in mothers and their children.

Aim

To discuss the implications of VD deficiency during pregnancy and the best VD supplementation to use in order to avoid risks for the mother and child.

Methods

PubMed was used to select all of the clinical studies published in the last 15 years concerning VD deficiency in pregnant women and its impact on the fetuses, neonates and infants, as well as the use of VD supplementation during pregnancy.

Results

Several studies have suggested that VD deficiency is associated with possible major outcomes in the preconception period, during pregnancy, perinatally and in childhood. A 25(OH)D concentration of >32 and <50–60 ng/mL seems to be associated with the lowest risk of disease, and the administration of 2,000 IU/day to pregnant and breastfeeding women seems to maintain adequate 25(OH)D levels. However, not all the experts agree with these conclusions because some of them do not think that VD deficiency can really cause extraskeletal manifestations and consider that the traditionally suggested 400–600 IU/day can be enough to permit an adequate bone development.

Conclusions

Despite an increasing amount of data seems to suggest that pregnant women need a greater amount of VD than recommended in the past, further studies are needed to determine how much VD has to be given to assure a regular evolution of the pregnancy and an adequate development of the fetus and the young child.

Keywords

Bone developmentPregnancyRespiratory infectionVitamin DVitamin D deficiencyVitamin D supplementation

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Nicola Principi
    • 1
  • Sonia Bianchini
    • 1
  • Elena Baggi
    • 1
  • Susanna Esposito
    • 1
  1. 1.Pediatric Clinic 1, Department of Pathophysiology and TransplantationUniversità degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilanItaly