European Journal of Nutrition

, Volume 52, Issue 1, pp 85–95

Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary

  • Auxiliadora López-Jiménez
  • Melissa García-Caballero
  • Miguel Ángel Medina
  • Ana R. Quesada
Original Contribution

DOI: 10.1007/s00394-011-0289-x

Cite this article as:
López-Jiménez, A., García-Caballero, M., Medina, M.Á. et al. Eur J Nutr (2013) 52: 85. doi:10.1007/s00394-011-0289-x
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Abstract

Background

The use of rosemary (Rosmarinus officinalis) leaves and their constituents as a source of dietary antioxidants and flavoring agents is continuously growing. Carnosol and carnosic acid, two major components of rosemary extracts, have shown activity for cancer prevention and therapy.

Aim of the study

In this study, we investigate the cytotoxic and anti-angiogenic activities of carnosol and carnosic acid, in order to get further insight into their mechanism of action.

Results

Our results demonstrate that the mentioned diterpenes inhibit certain functions of endothelial cells, namely, differentiation, proliferation, migration and proteolytic capability. Our data indicate that their growth inhibitory effect, exerted on proliferative endothelial and tumor cells, could be due to, at least in part, an induction of apoptosis. Inhibition of the mentioned essential steps of in vitro angiogenesis agrees with the observed inhibition of the in vivo angiogenesis, substantiated by using the chick chorioallantoic membrane assay.

Conclusions

The anti-angiogenic activity of carnosol and carnosic acid could contribute to the chemopreventive, antitumoral and antimetastatic activities of rosemary extracts and suggests their potential in the treatment of other angiogenesis-related malignancies.

Keywords

Angiogenesis Carnosic acid Carnosol Rosemary Chemoprevention 

Supplementary material

394_2011_289_MOESM1_ESM.pdf (30 kb)
Supplementary Methods. (PDF 30 kb)

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Auxiliadora López-Jiménez
    • 1
    • 2
  • Melissa García-Caballero
    • 1
    • 2
  • Miguel Ángel Medina
    • 1
    • 2
  • Ana R. Quesada
    • 1
    • 2
  1. 1.Department of Molecular Biology and Biochemistry, Faculty of SciencesUniversity of MálagaMálagaSpain
  2. 2.Unidad 741 de CIBER “de Enfermedades Raras”MálagaSpain

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