Original Contribution

European Journal of Nutrition

, Volume 51, Issue 7, pp 791-799

Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise

  • Javier Díaz-CastroAffiliated withDepartment of Physiology, University of GranadaInstitute of Nutrition and Food Technology “José Mataix Verdú”, Biomedical Research Centre, Health-Sciencies Technological Park, University of Granada
  • , Rafael GuisadoAffiliated withFaculty of Health Science, University of Granada
  • , Naroa KajarabilleAffiliated withDepartment of Physiology, University of GranadaInstitute of Nutrition and Food Technology “José Mataix Verdú”, Biomedical Research Centre, Health-Sciencies Technological Park, University of Granada
  • , Carmen GarcíaAffiliated withFaculty of Health Science, University of Granada
  • , Isabel M. GuisadoAffiliated withDepartment of Pharmacology, University of Granada
  • , Carlos de TeresaAffiliated withAndalussian Center of Sports Medicine
  • , Julio J. OchoaAffiliated withDepartment of Physiology, University of GranadaInstitute of Nutrition and Food Technology “José Mataix Verdú”, Biomedical Research Centre, Health-Sciencies Technological Park, University of Granada Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Background

Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.

Aim

The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q10 (CoQ10) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.

Methods

The participants were classified in two groups: CoQ10 group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.

Results

Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ10 during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ10 prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ10 supplementation reduced creatinine production.

Conclusions

CoQ10 supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.

Keywords

High-intensity (strenuous) exercise Coenzyme Q10 Oxidative damage Inflammation