European Journal of Nutrition

, Volume 50, Issue 2, pp 145–149

Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes

Authors

    • Cardiovascular Research Unit, Physiology Department, Health Science University CenterUniversity of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security
  • Esperanza Martínez-Abundis
    • Cardiovascular Research Unit, Physiology Department, Health Science University CenterUniversity of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security
  • José A. Robles-Cervantes
    • Cardiovascular Research Unit, Physiology Department, Health Science University CenterUniversity of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security
  • Viridiana Ramírez-Ramírez
    • Cardiovascular Research Unit, Physiology Department, Health Science University CenterUniversity of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security
  • Maria G. Ramos-Zavala
    • Cardiovascular Research Unit, Physiology Department, Health Science University CenterUniversity of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security
Short Communication

DOI: 10.1007/s00394-010-0123-x

Cite this article as:
González-Ortiz, M., Martínez-Abundis, E., Robles-Cervantes, J.A. et al. Eur J Nutr (2011) 50: 145. doi:10.1007/s00394-010-0123-x

Abstract

Purpose

To evaluate the effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes mellitus (T2DM).

Methods

A randomized, double-blind, placebo-controlled, pilot-scale clinical trial was carried out in 24 patients with T2DM. Twelve subjects received thiamine orally (150 mg), once daily during a fasting state for 1 month. An additional 12 patients (control group) were given placebo for the same period of time. Before and after the intervention, fasting glucose, A1C, creatinine, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, very low-density lipoprotein, high-sensitive C-reactive protein, interleukin 6, tumor necrosis factor-alpha, leptin and adiponectin levels were estimated. Wilcoxon’s signed-rank and Mann–Whitney U test were used for statistical analyses.

Results

There were significant decreases in glucose (6.7 ± 1.0 mmol/l vs. 6.0 ± 1.0 mmol/l, p = 0.024) before and after the intervention, respectively, and leptin concentrations (32.9 ± 13.3 ng/ml vs. 26.9 ± 12.8 ng/ml, p = 0.027) before and after the intervention, respectively, with thiamine administration. There were no changes with the rest of the measurements.

Conclusions

Thiamine administration for 1 month decreased glucose and leptin concentrations in drug-naïve patients with T2DM.

Keywords

ThiamineMetabolic profileCytokinesInflammatory markersType 2 diabetes

Copyright information

© Springer-Verlag 2010