European Journal of Nutrition

, Volume 49, Issue 8, pp 473–481

Dietary B vitamin intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh

Authors

  • Maria Argos
    • Department of Health StudiesThe University of Chicago
  • Paul J. Rathouz
    • Department of Health StudiesThe University of Chicago
  • Brandon L. Pierce
    • Department of Health StudiesThe University of Chicago
  • Tara Kalra
    • Department of Health StudiesThe University of Chicago
  • Faruque Parvez
    • Department of Environmental Health Sciences, Mailman School of Public HealthColumbia University
  • Vesna Slavkovich
    • Department of Environmental Health Sciences, Mailman School of Public HealthColumbia University
  • Alauddin Ahmed
    • Columbia University and The University of Chicago Research Office in Bangladesh
  • Yu Chen
    • Department of Environmental MedicineNew York University School of Medicine
    • Department of Health StudiesThe University of Chicago
Original Contribution

DOI: 10.1007/s00394-010-0106-y

Cite this article as:
Argos, M., Rathouz, P.J., Pierce, B.L. et al. Eur J Nutr (2010) 49: 473. doi:10.1007/s00394-010-0106-y

Abstract

Purpose

The objective of this analysis was to evaluate the effects of dietary B vitamin intakes on creatinine-adjusted urinary total arsenic concentration among individuals participating in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Araihazar, Bangladesh. Arsenic exposure is a major public health problem in Bangladesh, where nearly 77 million people have been chronically exposed to arsenic through the consumption of naturally contaminated groundwater. Dietary factors influencing the metabolism of ingested arsenic may potentially be important modifiers of the health effects of arsenic in this population.

Methods

Daily average B vitamin intakes from a validated food frequency questionnaire and laboratory data on drinking water and urinary arsenic concentrations among 9,833 HEALS cohort participants were utilized. Statistical analyses were conducted using generalized estimating equations incorporating knotted spline linear regression.

Results

Increasing dietary intakes of thiamin, niacin, pantothenic acid, and pyridoxine were found to significantly increase urinary total arsenic excretion, adjusted for daily arsenic intake from drinking water and other potential confounders.

Conclusions

These results suggest that higher intakes of certain B vitamins may enhance the excretion of arsenic from the body. This study offers new insights into modifiable dietary factors that relate to arsenic excretion and thus provides potential avenues for the prevention of arsenic-related health effects.

Keywords

ArsenicBangladeshB vitaminsCross-sectional analysis

Copyright information

© Springer-Verlag 2010