European Journal of Nutrition

, Volume 47, Supplement 2, pp 19–28

Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?

  • Steffen Loft
  • Peter Møller
  • Marcus S. Cooke
  • Rafal Rozalski
  • Ryszard Olinski
Article

DOI: 10.1007/s00394-008-2004-0

Cite this article as:
Loft, S., Møller, P., Cooke, M.S. et al. Eur J Nutr (2008) 47(Suppl 2): 19. doi:10.1007/s00394-008-2004-0

Abstract

Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.

Key words

antioxidants comet assay 8-oxodG oxidative stress oxidative damage to DNA 

Copyright information

© Spinger 2008

Authors and Affiliations

  • Steffen Loft
    • 1
  • Peter Møller
    • 1
    • 2
  • Marcus S. Cooke
    • 3
  • Rafal Rozalski
    • 4
  • Ryszard Olinski
    • 4
  1. 1.Institute of Public HealthUniversity of CopenhagenCopenhagenDenmark
  2. 2.Copenhagen KDenmark
  3. 3.University of LeicesterLeicesterUK
  4. 4.Dept. of Clinical Biochemistry, Collegium MedicumNicolaus Copernicus UniversityBydgoszczPoland

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