Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index
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- Konradsen, S., Ag, H., Lindberg, F. et al. Eur J Nutr (2008) 47: 87. doi:10.1007/s00394-008-0700-4
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Based on in vitro studies, it has been hypothesized that 1,25-dihydroxy vitamin D (1,25-vit D) may promote weight gain in humans, but previous studies have demonstrated conflicting results regarding the association between serum 1,25-vit D and body mass index (BMI).
Aim of the study
To evaluate the relation between serum 1,25-vit D and BMI.
Two thousand one hundred and eighty-seven subjects, recruited from a metabolic and medical lifestyle management clinic, were included in a cross-sectional study. BMI, 25-hydroxy vitamin D (25-OH-vit D) and 1,25-vit D were measured. The cohort was divided according to BMI in five groups (<25, 25–29.9, 30–34.9, 35–39.9 and >39.9 kg/m2). Statistical analyses were performed with multiple linear regression models. Age and gender were used as explanatory covariates.
With increasing BMI group, there was a significant decrease in both serum 25-OH-vit D and 1,25-vit D (P < 0.001). Those with BMI > 39.9 kg/m2 had 24% lower serum 25-OH-vit D levels and 18 % lower 1,25-vit D levels than those with BMI < 25 kg/m2.
There is an inverse association between BMI and the serum levels of 25-OH-vit D and 1,25-vit D. This makes it highly unlikely that high levels of circulating 1,25-vit D contribute to the development of obesity.