Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice
- José L. PeñalvoAffiliated withInstitute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center and Division of Clinical Chemistry, University of HelsinkiUniversidad Complutense de Madrid Email author
- , Anu HopiaAffiliated withRaisio Benecol Ltd.
- , Herman AdlercreutzAffiliated withInstitute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center and Division of Clinical Chemistry, University of Helsinki
Sesamin, a major lignan from sesame seeds has been associated with cholesterol reduction in previous reports, but recent studies suggested differences in the response to sesamin intake depending on the model studied as well as the nature of the sesamin preparation used.
The effect of pure sesamin epimer on serum lipids was studied in hypercholesterolemic LDL receptor-knockout mice under cholesterol fed condition.
Animals were randomly assigned to 4 groups, fed an atherogenic diet containing stanol ester, sesamin, combination of stanol ester and sesamin or a control diet with no additions.
The control group showed an almost 3-fold increase in serum cholesterol levels due to the atherogenic diet but no effect was seen for triglyceride levels. Stanol ester alone or together with sesamin significantly attenuated the elevation of the cholesterol levels.
Sesamin alone did not affect the elevation of the diet-induced cholesterol level and it did not enhance the effect of stanol ester.
Keywordscholesterol triglycerides lignans sesamin enterolignans stanol ester
- Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice
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- Available under Open Access This content is freely available online to anyone, anywhere at any time.
European Journal of Nutrition
Volume 45, Issue 8 , pp 439-444
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- Author Affiliations
- 1. Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center and Division of Clinical Chemistry, University of Helsinki, Finland
- 3. Universidad Complutense de Madrid, Madrid, Spain
- 2. Raisio Benecol Ltd., Raisio, Finland