European Journal of Nutrition

, Volume 45, Issue 2, pp 70–78

Homocysteine and cognitive function in institutionalised elderly

A cross–sectional analysis
  • M. Manders
  • E. Vasse
  • L. C. P. G. M. de Groot
  • W. A. van Staveren
  • J. G. Bindels
  • H. J. Blom
  • W. H. L. Hoefnagels
ORIGINAL CONTRIBUTION

DOI: 10.1007/s00394-005-0566-7

Cite this article as:
Manders, M., Vasse, E., de Groot, L.C.P.G.M. et al. Eur J Nutr (2006) 45: 70. doi:10.1007/s00394-005-0566-7
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Summary

Background

Several cross–sectional, case–control and prospective studies revealed a relation between homocysteine and cognitive function or dementia. These studies included either patient populations or healthy, community– dwelling elderly people.

Aim of the study

In this study we tested the hypothesis that homocysteine was inversely associated with cognitive function in a population of institutionalised elderly (aged ≥ 60 y; n = 157).

Methods

For testing this hypothesis baseline data of a recently conducted intervention study in institutionalised elderly (median age 83 years) were used. Cognitive function was evaluated by the cognitive subscale of the Alzheimer's disease Assessment Scale (ADAS–cog). The association between fasting plasma homocysteine level and cognitive function was investigated by multiple linear regression analysis.

Results

In the crude model homocysteine concentration was not significantly related to ADAS–cog score (β = 0.061; p = 0.45).Age was found to be related to ADAS–cog score (β = 0.161; p < 0.05). Adjusting for age did however not result in a relation between homocysteine and cognitive function.

Conclusions

In our study no association was found between homocysteine and cognitive function in a population of very old institutionalised subjects.

Key words

homocysteine cognitive function institutionalised elderly cross sectional study 

Copyright information

© Steinkopff-Verlag 2005

Authors and Affiliations

  • M. Manders
    • 1
  • E. Vasse
    • 1
  • L. C. P. G. M. de Groot
    • 1
  • W. A. van Staveren
    • 1
  • J. G. Bindels
    • 2
  • H. J. Blom
    • 3
  • W. H. L. Hoefnagels
    • 3
  1. 1.Division of Human NutritionWageningen UniversityEV WageningenThe Netherlands
  2. 2.Numico Research WageningenWageningenThe Netherlands
  3. 3.University Medical Centre St RadboudNijmegenThe Netherlands

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