Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study
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- Sinning, C., Keller, T., Zeller, T. et al. Clin Res Cardiol (2014) 103: 211. doi:10.1007/s00392-013-0640-8
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Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.
In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35–74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.
In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3 % overall, 89.9 % men (N = 1,888), 74.4 % women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E′ correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.
Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.
KeywordsHigh-sensitivity assayed troponin ICardiac structureCardiac functionEndothelial dysfunctionPopulation study
Body mass index
Coronary artery disease
Common carotid artery
Coefficient of variation
Estimated glomerular filtration rate
Gutenberg Health Study
Troponin I as measured by a high-sensitivity assay
Troponin T as measured by a high-sensitivity assay
Limit of detection
Left ventricular end-diastolic diameter
Left ventricular ejection fraction
Left ventricular mass
N-terminal pro-B-type natriuretic peptide