Clinical Research in Cardiology

, Volume 102, Issue 7, pp 495–503

Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application

  • Christoph Sinning
  • Lars Lillpopp
  • Sebastian Appelbaum
  • Francisco Ojeda
  • Tanja Zeller
  • Renate Schnabel
  • Edith Lubos
  • Annika Jagodzinski
  • Till Keller
  • Thomas Munzel
  • Christoph Bickel
  • Stefan Blankenberg
Original Paper

DOI: 10.1007/s00392-013-0555-4

Cite this article as:
Sinning, C., Lillpopp, L., Appelbaum, S. et al. Clin Res Cardiol (2013) 102: 495. doi:10.1007/s00392-013-0555-4

Abstract

Background

Severity of coronary artery disease (CAD) is related to cardiovascular outcome. We aimed to assess the long-term follow-up depending on Synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) and Gensini score for prognosis. Both scores increase with complexity and thus reflect risk of cardiovascular events.

Methods and results

We determined complexity and extent of CAD by the SYNTAX and Gensini score in the AtheroGene cohort (N = 1,974, with 22.6 % women). The endpoint was non-fatal myocardial infarction (N = 132) and cardiovascular death (N = 159) over a median follow-up of 5.4 (Q1: 5.23/Q3: 5.57) years up to 8 years maximum (follow-up rate 99.4 %).

For SYNTAX score, the following distribution was used: low (≤22, N = 1,404), medium (23–32, N = 314), high score (>32, N = 256). Gensini score was split into thirds. Cox regression analysis showed a hazard ratio (HR) of 1.5 (95 % confidence interval 1.16–1.95; p = 0.0024) for the log transformed SYNTAX score in a fully adjusted model and a HR of 1.41 (95 % CI 1.13–1.77; p = 0.0025) for the Gensini score. The SYNTAX score alone had a C-index of 0.62, whereas adding clinical variables increased the C-index to 0.67. Similar results were obtained for the Gensini score. Regarding the SYNTAX score using net reclassification index, discrimination of events and non-events was enhanced by 37.2 % in a model of clinical variables and biomarkers and by 31.8 % for the Gensini score.

Conclusion

The SYNTAX and Gensini score in combination with clinical variables could be used to predict the cardiovascular prognosis during a long-term follow-up of up to 8 years in CAD patients.

Keywords

Coronary artery disease Prognosis Risk stratification SYNTAX score Gensini score 

Abbreviations

ACS

Acute coronary syndrome

CAD

Coronary artery disease

CABG

Coronary artery bypass grafting

CI

Confidence interval

CRP

C-reactive protein

HDL-cholesterol

High density lipoprotein

HR

Hazard ratio

LDL-cholesterol

Low density lipoprotein

Nt-proBNP

N-terminal pro B-type natriuretic peptide

NRI

Net reclassification improvement

NSTEMI

Non-ST-segment elevation infarction

PCI

Percutaneous coronary intervention

SD

Standard deviation

STEMI

ST segment elevation infarction

SYNTAX

Synergy between percutaneous coronary intervention with taxus and cardiac surgery

Supplementary material

392_2013_555_MOESM1_ESM.docx (12 kb)
Supplementary material 1 (DOCX 12 kb)
392_2013_555_MOESM2_ESM.docx (12 kb)
Supplementary material 2 (DOCX 11 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Christoph Sinning
    • 1
  • Lars Lillpopp
    • 2
  • Sebastian Appelbaum
    • 1
  • Francisco Ojeda
    • 1
  • Tanja Zeller
    • 1
  • Renate Schnabel
    • 1
  • Edith Lubos
    • 1
  • Annika Jagodzinski
    • 1
  • Till Keller
    • 1
  • Thomas Munzel
    • 2
  • Christoph Bickel
    • 2
    • 3
  • Stefan Blankenberg
    • 1
  1. 1.Department of General and Interventional CardiologyUniversity Heart Center HamburgHamburgGermany
  2. 2.II Department of MedicineUniversity Medical Center, Johannes Gutenberg UniversityMainzGermany
  3. 3.Department of Internal MedicineFederal Armed Forces Central HospitalKoblenzGermany

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