Clinical Research in Cardiology

, Volume 102, Issue 4, pp 269–278

Generic and disease-specific health-related quality of life in patients with chronic systolic heart failure: impact of depression

  • Marion Schowalter
  • Götz Gelbrich
  • Stefan Störk
  • Jan-Philip Langguth
  • Caroline Morbach
  • Georg Ertl
  • Hermann Faller
  • Christiane E. Angermann
Original Paper

DOI: 10.1007/s00392-012-0531-4

Cite this article as:
Schowalter, M., Gelbrich, G., Störk, S. et al. Clin Res Cardiol (2013) 102: 269. doi:10.1007/s00392-012-0531-4

Abstract

Aims

Heart failure is known to profoundly affect health-related quality of life (HRQoL). We aimed to describe both generic and disease-specific HRQoL in a large community-based sample of patients with systolic heart failure (SHF) and to identify important somatic and psychosocial correlates.

Methods and results

Seven hundred and two patients, 67 ± 12 years old, 71 % men, with distributions of New York Heart Association (NYHA) functional classes I/II/III/IV of 2/55/39/4 % were included in this cross-sectional analysis. Generic HRQoL was measured with the SF-36 health survey, disease-specific HRQoL with the Kansas City Cardiomyopathy Questionnaire, and depression with the self-reported Patient Health Questionnaire (PHQ-9). Both generic- and disease-specific HRQoL measurements indicated moderate to poor HRQoL. The KCCQ scores demonstrated higher sensitivity to the varying levels of heart failure severity as compared to the SF-36 scores. Patients with either a minor (15 %) or a major depression (24 %) reported significantly and substantially lower HRQoL (p < .001) than patients without depression did. In multivariable regression analyses, depression accounted for the largest part of the variance of both generic and specific HRQoL (12 and 36 %, respectively), whereas most biomedical variables had no or only a marginal influence.

Conclusion

Patients with SHF suffer from severe limitations of HRQoL. Depression was the most important correlate of both generic and disease-specific HRQoL.

Keywords

Chronic heart failureGeneric health-related quality of lifeDisease-specific health-related quality of lifeDepression

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Marion Schowalter
    • 1
  • Götz Gelbrich
    • 3
    • 5
  • Stefan Störk
    • 2
  • Jan-Philip Langguth
    • 2
  • Caroline Morbach
    • 2
  • Georg Ertl
    • 2
  • Hermann Faller
    • 1
  • Christiane E. Angermann
    • 2
  1. 1.Department of Medical Psychology, Medical Sociology and Rehabilitation SciencesUniversity of WürzburgWürzburgGermany
  2. 2.Department of Internal Medicine I/Center of Cardiovascular MedicineUniversity Hospital WürzburgWürzburgGermany
  3. 3.Coordination Center for Clinical TrialsUniversity of LeipzigLeipzigGermany
  4. 4.Institute of Psychotherapy und Medical PsychologyUniversity of WürzburgWürzburgGermany
  5. 5.Institute of Clinical Epidemiology and BiometryUniversity of WürzburgWürzburgGermany