Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction
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Low serum level of vitamin D was shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is a global problem, and is an Iranian problem as well. To the best of our knowledge, this was the first study on acute myocardial infarction that evaluates the correlation of vitamin D level with inpatients’ outcomes, particularly on the early biomarkers of myocardial remodeling.
In a prospective study, patients with acute ST segment elevation myocardial infarction were included. The patients’ 25 (OH) D levels were identified and the associations with clinical characteristics, including early remodeling biomarkers and in-hospital outcomes, were investigated.
From the 139 included patients, 80.5% were male. The 25 (OH) deficiency was present in 72.7% of the patients. Hypertension and positive history of cardiovascular drug use were risk factors for the presence of low vitamin D levels (OR = 2.92; CI = 1.34–6.37, P < 0.05) and (OR = 2.36; CI = 1.05–5.29, P < 0.05), respectively. Moreover, a significant positive relationship between the inpatients’ survival and the concentration of vitamin D was present (P < 0.001). By performing a multivariate analysis, we found that there was a significant inverse relationship between the level of 25 (OH) D and the level of MMP-9 after 72 h (P = 0.011).
The results of our study revealed a significant inverse relationship between serum MMP-9 as a biomarker of early remodeling and the level of 25(OH) D in patients after an acute myocardial infarction. Moreover, low level of vitamin D was associated with patients’ mortality in this study.
- Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction
Clinical Research in Cardiology
Volume 101, Issue 5 , pp 321-327
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- Vitamin D
- Matrix metalloproteinase
- Myocardial Infarction
- Industry Sectors
- Author Affiliations
- 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O.Box 14155/6451, 1417614411, Tehran, Iran
- 2. Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran