Clinical Research in Cardiology

, Volume 101, Issue 5, pp 321–327

Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction

  • Hossein Khalili
  • Azita Hajhossein Talasaz
  • Mojtaba Salarifar
Original Paper

DOI: 10.1007/s00392-011-0394-0

Cite this article as:
Khalili, H., Talasaz, A.H. & Salarifar, M. Clin Res Cardiol (2012) 101: 321. doi:10.1007/s00392-011-0394-0



Low serum level of vitamin D was shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is a global problem, and is an Iranian problem as well. To the best of our knowledge, this was the first study on acute myocardial infarction that evaluates the correlation of vitamin D level with inpatients’ outcomes, particularly on the early biomarkers of myocardial remodeling.


In a prospective study, patients with acute ST segment elevation myocardial infarction were included. The patients’ 25 (OH) D levels were identified and the associations with clinical characteristics, including early remodeling biomarkers and in-hospital outcomes, were investigated.


From the 139 included patients, 80.5% were male. The 25 (OH) deficiency was present in 72.7% of the patients. Hypertension and positive history of cardiovascular drug use were risk factors for the presence of low vitamin D levels (OR = 2.92; CI = 1.34–6.37, P < 0.05) and (OR = 2.36; CI = 1.05–5.29, P < 0.05), respectively. Moreover, a significant positive relationship between the inpatients’ survival and the concentration of vitamin D was present (P < 0.001). By performing a multivariate analysis, we found that there was a significant inverse relationship between the level of 25 (OH) D and the level of MMP-9 after 72 h (P = 0.011).


The results of our study revealed a significant inverse relationship between serum MMP-9 as a biomarker of early remodeling and the level of 25(OH) D in patients after an acute myocardial infarction. Moreover, low level of vitamin D was associated with patients’ mortality in this study.


Vitamin DMatrix metalloproteinaseMyocardial InfarctionRemodeling

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hossein Khalili
    • 1
  • Azita Hajhossein Talasaz
    • 1
  • Mojtaba Salarifar
    • 2
  1. 1.Department of Clinical PharmacyFaculty of Pharmacy, Tehran University of Medical SciencesTehranIran
  2. 2.Department of CardiologyTehran Heart Center, Tehran University of Medical SciencesTehranIran