, Volume 100, Issue 4, pp 373-377
Date: 14 Dec 2010

Acquired long QT interval in a recurrent septic female patient with polymorphic ventricular tachycardia due to primary acute adrenal insufficiency

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Sirs:

Adrenal insufficiency (AI), primarily presenting as an adrenal crisis (AC), is a life-threatening emergency since it may result in a severe hypotensive crisis and impaired vigilance, together with pain in the muscles, joints, or abdomen and fever [1]. Primary AI has a prevalence of 93–140 per million and an incidence of 4.7–6.2 per million in white populations [2]. These numbers are higher than those reported during the 1960s and 1970s, suggesting an increasing incidence of autoimmune adrenalitis. The age at diagnosis peaks in the fourth decade of life, with women more frequently affected than men [3]. Because of the unspecific symptoms, diagnosis is often delayed despite early diagnosis is necessary and might positively influence subjective health status in patients with AI [4]. Prompt therapeutic management including fluid replacement and glucocorticoid (GC) administration is required in the treatment of AC. Polymorphic ventricular tachycardia (PVT) is a rhythm emergency which m ...