Clinical Research in Cardiology

, Volume 100, Issue 1, pp 77–84

Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease

  • Juliano Lara Fernandes
  • Carlos Vicente SerranoJr
  • Flavia Toledo
  • Maria Fernanda Hunziker
  • Augusto Zamperini
  • Fabio H Teo
  • Romulo T Oliveira
  • Maria Heloisa Blotta
  • Maria Urbana Rondon
  • Carlos Eduardo Negrão
Original Paper

DOI: 10.1007/s00392-010-0215-x

Cite this article as:
Lara Fernandes, J., Serrano, C.V., Toledo, F. et al. Clin Res Cardiol (2011) 100: 77. doi:10.1007/s00392-010-0215-x

Abstract

Background

Few studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program.

Methods

34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that.

Results

In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-γ [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [−0.29 (0.84) mg/L vs. −0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively].

Conclusions

Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.

Keywords

Inflammation Coronary artery disease Exercise Atherosclerosis 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Juliano Lara Fernandes
    • 1
  • Carlos Vicente SerranoJr
    • 2
  • Flavia Toledo
    • 2
  • Maria Fernanda Hunziker
    • 2
  • Augusto Zamperini
    • 1
  • Fabio H Teo
    • 1
  • Romulo T Oliveira
    • 1
  • Maria Heloisa Blotta
    • 1
  • Maria Urbana Rondon
    • 2
  • Carlos Eduardo Negrão
    • 2
  1. 1.University of Campinas (Unicamp)CampinasBrazil
  2. 2.Heart InstituteUniversity of São Paulo Medical SchoolSão PauloBrazil

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