Clinical Research in Cardiology

, Volume 99, Issue 12, pp 781–786

Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome

Authors

  • Yanping Zha
    • Department of CardiologyProvincial Hospital Affiliated to Shandong University
  • Yong Chen
    • Department of CardiologyProvincial Hospital Affiliated to Shandong University
  • Fayun Xu
    • Department of CardiologyProvincial Hospital Affiliated to Shandong University
  • Jie Zhang
    • Department of Central LaboratoryProvincial Hospital Affiliated to Shandong University
  • Tian Li
    • Department of Clinical BiochemistryProvincial Hospital Affiliated to Shandong University
  • Chuanyan Zhao
    • Department of CardiologyProvincial Hospital Affiliated to Shandong University
    • Department of CardiologyProvincial Hospital Affiliated to Shandong University
Original Paper

DOI: 10.1007/s00392-010-0183-1

Cite this article as:
Zha, Y., Chen, Y., Xu, F. et al. Clin Res Cardiol (2010) 99: 781. doi:10.1007/s00392-010-0183-1

Abstract

Objectives

A recent study shows that ADAMTS4 is expressed in macrophage-rich areas of human atherosclerotic carotid plaques and coronary unstable plaques, suggesting a pathogenic role of ADAMTS4 in the development of acute coronary syndrome (ACS). We investigated (a) whether the expression level of ADAMTS4 in plasma and peripheral blood mononuclear cells was affected; and (b) whether there was a relationship with hs-CRP level and the stability of coronary atherosclerotic plaque in patients with ACS.

Methods

Our study included 30 normal controls and 120 patients including 40 with stable angina (SA), 50 with unstable angina (UA), and 30 with acute myocardial infarction (AMI). The expression of ADAMTS4 in monocytes was analyzed by RT-PCR and plasma ADAMTS4 level was determined by ELISA. All coronary stenosis with >30% diameter reduction was assessed by angiographic coronary stenosis morphology.

Results

Patients with ACS showed a significant increase of ADAMTS4 (2.7 ± 0.4) expression in monocytes compared with controls (1.1 ± 0.2) and the SA group (1.3 ± 0.2) (P < 0.001). Plasma ADAMTS4 also showed a higher level in ACS patients (100.2 ± 31.6 ng/ml) than in control (47.5 ± 9.0 ng/ml, P < 0.001) and the SA group (54.3 ± 13.2 ng/ml, P < 0.001). Moreover, we found a positive correlation between hs-CRP and ADAMTS4 expression in monocytes as well as in plasma. There was also a positive correlation of ADAMTS4 expression in monocytes and plasma with complex coronary stenosis (r1 = 0.61, r2 = 0.57, P < 0.001).

Conclusions

Patients with ACS showed increased ADAMTS4 expression, which may aggravate the development of atherosclerosis and instability of atherosclerotic plaques. Therefore, the ADAMTS4 expression may be a valuable marker for predicting the severity of ACS.

Keywords

ADAMTS4Acute coronary syndromeUnstable plaquePeripheral blood mononuclear cells

Copyright information

© Springer-Verlag 2010