Effect of selective and non-selective β-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure
- Dragan KovačićAffiliated withDepartment of Cardiology, General and Teaching Hospital Celje
- , Matej MarinšekAffiliated withDepartment of Cardiology, General and Teaching Hospital Celje
- , Lidija GobecAffiliated withCentral Laboratory, General and Teaching Hospital Celje
- , Mitja LainščakAffiliated withDepartment of Internal Medicine, General Hospital Murska Sobota
- , Matej PodbregarAffiliated withCenter for intensive care medicine, University Clinical Center Ljubljana Email author
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Chronic heart failure (CHF) is characterized by increased insulin resistance and hyperleptinaemia. We aimed to study effects of selective and non-selective β-blockers on body weight, insulin resistance, plasma concentrations of leptin and resistin in patients with CHF.
Twenty-six non-cachectic β-blocker-naive patients with CHF were randomized and treated with either carvedilol or bisoprolol. Body weight, plasma concentrations of leptin, resistin, fasting glucose and insulin were measured at baseline and after 6 months of therapy. Insulin resistance was estimated by homeostasis model assessment- estimated insulin resistance (HOMA-IR).
Body weight increased significantly in the carvedilol group (mean change + 2.30 kg, p = 0.023) while it did not change in the bisoprolol group (mean change –0.30 kg, p = 0.623) (ns between groups). Plasma leptin concentration increased only in the carvedilol group (mean change + 4.20 ng/ml, p = 0.019) (ns between groups). Fasting glucose and resistin remained unchanged in both groups. After 6 months, mean plasma insulin concentration changed significantly differently (p = 0.015) in the bisoprolol (mean change +3.1 µU/ml) compared to the carvedilol group (mean change –6.3 µU/ml) and HOMA-IR was consequently higher in the bisoprolol compared to the carvedilol group (5.2 ± 4.2 vs 2.8 ± 1.6, p = 0.046).
This study found different metabolic effects of carvedilol and bisoprolol in non-cachectic patients with CHF. With unchanged fasting plasma glucose concentration after 6 months of treatment, carvedilol significantly decreased plasma insulin concentration and insulin resistance compared to bisoprolol.
Key wordsbisoprolol carvedilol chronic heart failure insulin resistance leptin resistin
- Effect of selective and non-selective β-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure
Clinical Research in Cardiology
Volume 97, Issue 1 , pp 24-31
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- chronic heart failure
- insulin resistance
- Industry Sectors
- Author Affiliations
- 2. Department of Cardiology, General and Teaching Hospital Celje, Celje, Slovenia
- 3. Central Laboratory, General and Teaching Hospital Celje, Celje, Slovenia
- 4. Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia
- 1. Center for intensive care medicine, University Clinical Center Ljubljana, Ljubljana, Slovenia