International Journal of Colorectal Disease

, Volume 28, Issue 9, pp 1295–1306

Infliximab administration prior to surgery does not increase surgical site infections in patients with ulcerative colitis

  • Motoi Uchino
  • Hiroki Ikeuchi
  • Hiroki Matsuoka
  • Toshihiro Bando
  • Kaoru Ichiki
  • Kazuhiko Nakajima
  • Naohiro Tomita
  • Yoshio Takesue
Original Article

DOI: 10.1007/s00384-013-1700-2

Cite this article as:
Uchino, M., Ikeuchi, H., Matsuoka, H. et al. Int J Colorectal Dis (2013) 28: 1295. doi:10.1007/s00384-013-1700-2
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Abstract

Purpose

The high incidence of infectious complications in ulcerative colitis (UC) is generally recognized to be due to several factors related to a compromised host. In our previous study, a high dose of corticosteroid was shown to be a risk factor for surgical site infection (SSI). Recently, infliximab (IFX) has been used for refractory UC. In this study, the effect of IFX on the occurrence of infectious postoperative complications for UC was evaluated, because it remains controversial.

Method

A total of 196 UC patients who underwent laparotomy between January 2010 and September 2012 were included. Possible factors related to complications were analyzed to identify significant predictors.

Results

Twenty-two patients had IFX before surgery. The overall incidence of SSI was 47/196 (24.0 %). The incidence of infections, including SSI and other infections, was 69/196 (35.2 %). On multivariate analysis, national nosocomial infection surveillance (NNIS) risk index ≥2 (p<0.01) and preoperative prednisolone dose ≥0.2 mg/kg/day (p = 0.01) were identified as independent risk factors for overall SSI; NNIS risk index ≥2 (p <0.01) and duration from onset of UC ≥6.3 years (p = 0.045) were identified as independent risk factors for incisional SSI; contaminated wound class (p <0.01), preoperative hospital stay ≥6 days (p = 0.048), severe/fulminant disease activity (p = 0.04), and pancolitis (p = 0.02) were identified as independent risk factors for organ/space SSI; and contaminated wound (p < 0.01), severe/fulminant disease activity (p = 0.02), and age at surgery ≥43 years (p = 0.047) were identified as independent risk factors for total infectious complications.

Conclusion

IFX administration was not associated with infectious complications for UC surgery.

Keywords

Ileal-pouch anal anastomosis Infliximab Restorative proctocolectomy Surgical site infection Ulcerative colitis 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Motoi Uchino
    • 1
  • Hiroki Ikeuchi
    • 1
  • Hiroki Matsuoka
    • 1
  • Toshihiro Bando
    • 1
  • Kaoru Ichiki
    • 2
  • Kazuhiko Nakajima
    • 2
  • Naohiro Tomita
    • 1
  • Yoshio Takesue
    • 2
  1. 1.Department of SurgeryHyogo College of MedicineNishinomiyaJapan
  2. 2.Department of Infection Control and PreventionHyogo College of MedicineNishinomiyaJapan

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