International Journal of Colorectal Disease

, Volume 27, Issue 3, pp 277–286

Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Authors

  • Chun-Chi Lin
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
    • Department of Medical Research and EducationTaipei Veterans General Hospital
  • Yi-Ling Lai
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
  • Tzu-Chen Lin
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
  • Wei-Shone Chen
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
  • Jeng-Kai Jiang
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
  • Shung-Haur Yang
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
  • Huann-Sheng Wang
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
  • Yuan-Tzu Lan
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
  • Wen-Yih Liang
    • Department of PathologyTaipei Veterans General Hospital
  • Hui-Mei Hsu
    • Oncology Case Manager, Department of NursingTaipei Veterans General Hospital
  • Jen-Kou Lin
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
    • Division of Colon and Rectal Surgery, Department of SurgeryTaipei Veterans General Hospital
    • National Yang-Ming University
Original Article

DOI: 10.1007/s00384-011-1341-2

Cite this article as:
Lin, C., Lai, Y., Lin, T. et al. Int J Colorectal Dis (2012) 27: 277. doi:10.1007/s00384-011-1341-2

Abstract

Purpose

The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated.

Methods

Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed.

Results

From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p = 0.001), proximally located (76.7% vs. 34.5%, p = 0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p = 0.001) and female predominance (56.7% vs. 30.2%, p = 0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241–0.872, p = 0.017).

Conclusions

Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

Keywords

Colon cancerPrognosisMicrosatelliteMSIMismatch repairReplication error

Copyright information

© Springer-Verlag 2011