International Journal of Colorectal Disease

, Volume 27, Issue 2, pp 193–198

Comparison between quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and results of histopathological scoring in ulcerative colitis

  • Christiane Girlich
  • Doris Schacherer
  • Ernst Michael Jung
  • Frank Klebl
  • Elisabeth Huber
Original Article

DOI: 10.1007/s00384-011-1300-y

Cite this article as:
Girlich, C., Schacherer, D., Jung, E.M. et al. Int J Colorectal Dis (2012) 27: 193. doi:10.1007/s00384-011-1300-y

Abstract

Purpose

In ulcerative colitis (UC), endoscopic methods are preferred for assessment of extent and activity of disease. Due to the invasive nature of endoscopical examinations, replacement by other, reliable imaging procedures would be helpful. Contrast-enhanced ultrasound (CEUS) in combination with perfusion assessment using a specific quantification software might be such a new diagnostic tool. Thus, we compared the findings of CEUS with the results of endoscopically taken specimens applying a histopathological scoring system.

Methods

We prospectively evaluated 15 patients with proven UC undergoing endoscopy. CEUS was performed and the quantification software Qontrast® applied to obtain contrast-enhanced sonographic perfusion maps. Moreover, in each patient C-reactive protein (CRP) was measured and taken biopsies were assessed using an advanced scoring system. Four patients had to be excluded from final analysis.

Results

There was a trend to higher Peak (%) values with increasing histological inflammation. Furthermore, a strong negative correlation between the ratio TTP (s)/Peak (%) (Spearman’s correlation r = −0.761, p < 0.01) was found. There was no significant relationship between CRP and histopathological scoring or CEUS parameters, respectively.

Conclusion

Quantitative evaluation with CEUS, particularly the calculation of the ratio TTP (s)/Peak (%), provides a simple method for assessment of inflammatory activity in UC.

Keywords

Ulcerative colitis Contrast-enhanced ultrasound (CEUS) Histopathological scoring C-reactive protein 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Christiane Girlich
    • 1
  • Doris Schacherer
    • 1
  • Ernst Michael Jung
    • 2
  • Frank Klebl
    • 1
  • Elisabeth Huber
    • 3
  1. 1.Department of Internal Medicine IUniversity of RegensburgRegensburgGermany
  2. 2.Institute of RadiologyUniversity of RegensburgRegensburgGermany
  3. 3.Institute of PathologyUniversity of RegensburgRegensburgGermany

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