International Journal of Colorectal Disease

, Volume 26, Issue 4, pp 415–421

Laparoscopic-assisted versus open surgery for rectal cancer: a meta-analysis of randomized controlled trials on oncologic adequacy of resection and long-term oncologic outcomes

  • Mei-Jin Huang
  • Jing-Lin Liang
  • Hui Wang
  • Liang Kang
  • Yan-Hong Deng
  • Jian-Ping Wang
Original Article

DOI: 10.1007/s00384-010-1091-6

Cite this article as:
Huang, M., Liang, J., Wang, H. et al. Int J Colorectal Dis (2011) 26: 415. doi:10.1007/s00384-010-1091-6

Abstract

Background

Whether laparoscopic-assisted surgery (LS) can achieve the same oncologic outcomes compared with open surgery (OS) for rectal cancer remains controversial. The aim of this meta-analysis of randomized controlled trials (RCTs) is to compare oncologic adequacy of resection and long-term oncologic outcomes of LS with OS in the treatment of rectal cancer.

Methods

Literature searches of electronic databases (Pubmed, Embase, Web of Science, and Cochrane Library) and manual searches were performed to identify RCTs comparing values of oncologic adequacy of resection, recurrence, and survival following LS and OS.

Results

Six RCTs enrolling 1,033 participants were included in the meta-analysis. LS was associated with similar number of lymph nodes harvested and a similar distal tumor-free margin. LS was associated with a slightly high circumferential resection margin (CRM) positive rate with no significant difference (7.94% vs. 5.37%; risk ratio [RR], 1.13; P = 0.63). There was no significant difference between the two groups in local recurrence (RR, 0.55; P = 0.21). The 3-year overall survival advantage for LS over OS was not statistically significantly different (hazard ratio [HR], 0.76; P = 0.11). The 3-year disease-free survival was not significantly different between the two groups (HR, 1.16; P = 0.64).

Conclusions

The meta-analysis suggests that there are no differences between laparoscopic-assisted and open surgery in terms of number of lymph nodes harvested, involvement of CRM, local recurrence, 3-year overall survival, and disease-free survival for rectal cancer. However, more high-quality studies are needed for further analysis due to the small number of included studies.

Keywords

Rectal cancerLaparoscopic surgeryOpen surgeryMeta-analysis

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Mei-Jin Huang
    • 1
  • Jing-Lin Liang
    • 1
  • Hui Wang
    • 1
  • Liang Kang
    • 1
  • Yan-Hong Deng
    • 1
  • Jian-Ping Wang
    • 1
  1. 1.Department of Colorectal Surgery, The Sixth Affiliated Hospital (Guangdong Gastrointestinal Hospital)Sun Yat-sen UniversityGuangzhouPeople’s Republic of China