International Journal of Colorectal Disease

, Volume 26, Issue 1, pp 29–35

Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma

  • Yinling Mao
  • Zhiwei Li
  • Changjie Lou
  • Yanqiao Zhang
Original Article

DOI: 10.1007/s00384-010-1090-7

Cite this article as:
Mao, Y., Li, Z., Lou, C. et al. Int J Colorectal Dis (2011) 26: 29. doi:10.1007/s00384-010-1090-7

Abstract

Purpose

Constitutive activation of signal transducer and activator of transcription-5 (Stat5) was recently found to be associated with tumor progression through stimulating cell proliferation and preventing apoptosis. However, it is not clear how activated Stat5 is expressed in colon cancer. We aimed to investigate the correlation between phosphorylated Stat5 (p-Stat5) expression and cell cycle regulators (cyclin D1) expression in colonic adenocarcinoma and the relationship between expression of these two proteins and various clinicopathological parameters, including overall survival.

Methods

P-Stat5 and cyclin D1 expression were determined by immunohistochemical staining from 169 cases of resected colonic adenocarcinoma specimens.

Results

P-Stat5 expression correlated with cyclin D1 expression (r = 0.250, P = 0.001). P-Stat5-positive staining was associated with the depth of tumor invasion (P = 0.002). Univariate survival analysis showed that lymph node metastasis, distant metastasis, TNM stage (all P < 0.0001), T stage (P = 0.024), p-Stat5-positive expression (P = 0.002), and cyclin D1-positive expression (P = 0.039) were associated with shorter survival in patients with colonic adenocarcinoma. Multivariate survival analysis showed that only distant metastasis (P < 0.001; hazard ratio [HR] = 4.96), TNM stage (P < 0.001; HR = 9.80), and p-Stat5 overexpression (P = 0.020; HR = 1.84) were independent predictors of poor prognosis.

Conclusions

Our findings provide the first evidence that p-Stat5 may play an important role in cyclin D1 overexpression and contribute to colonic adenocarcinoma progression.

Keywords

Colon carcinoma Immunohistochemistry Prognosis Signal transducer and activator of transcription-5 (Stat5) Cell cycle regulators (cyclin D1) 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Yinling Mao
    • 1
  • Zhiwei Li
    • 1
  • Changjie Lou
    • 1
  • Yanqiao Zhang
    • 2
  1. 1.Department of Gastrointestinal Medical OncologyThe Affiliated Tumor Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of Gastrointestinal Medical OncologyThe Affiliated Tumor Hospital of Harbin Medical University, Institute of treatment and prevention of tumour of Heilongjiang ProvinceHarbinChina

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