International Journal of Colorectal Disease

, Volume 25, Issue 9, pp 1087–1092

Clinicopathological characteristics of rectal carcinoids

  • Sang Nam Yoon
  • Chang Sik Yu
  • Ui Sup Shin
  • Chan Wook Kim
  • Seok-Byung Lim
  • Jin Cheon Kim
Original Article

DOI: 10.1007/s00384-010-0949-y

Cite this article as:
Yoon, S.N., Yu, C.S., Shin, U.S. et al. Int J Colorectal Dis (2010) 25: 1087. doi:10.1007/s00384-010-0949-y

Abstract

Purposes

Carcinoids are heterogeneous neuroendocrine tumors with malignant potential. The rectum is the third most common location for gastrointestinal carcinoids. We assessed the clinicopathological characteristics of rectal carcinoids.

Methods

A retrospective study of 203 patients treated for rectal carcinoids at the Asan Medical Center, Seoul, Republic of Korea from 1991 to 2007.

Results

The patients were on average 51 (18–83) years old. The male-to-female ratio was 1.48:1. Over half (62.1%) of the patients were asymptomatic. The most frequent symptoms in the symptomatic patients were abdominal pain (11.1%) and hematochezia (10.7%). Local excision was applied to 92.1%, low anterior resection to 4.9%, and biopsy only to 3.0% of total patients. Initially, 4.4% presented with distant metastasis. Distant metastasis rates for tumors ≤1 cm, >1 to ≤2 cm, and >2 cm were 1.7% (3/177), 15.0% (3/20), and 50.0% (3/6), respectively. In the follow-up period, three patients showed recurrences. The size, lymphovascular invasion, perineural invasion, and T and N stages were associated with distant metastasis. The overall 5-year survival rate was 94.0%. The TNM stage and presence of lymphovascular invasion were associated with lower survival.

Conclusions

The chance that a rectal carcinoid will develop distant metastases increases as the tumor increases in size, lymphovascular invasion or perineural invasion is present, and T and N stages increase. The TNM stage and presence of lymphovascular invasion were associated with lower survival. Treatment plan should be chosen carefully considering above factors.

Keywords

Rectal carcinoidsTumor sizeDepth of invasionLymph node metastasisLymphovascular invasionPerineural invasionDistant metastasis

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Sang Nam Yoon
    • 1
  • Chang Sik Yu
    • 1
  • Ui Sup Shin
    • 1
  • Chan Wook Kim
    • 1
  • Seok-Byung Lim
    • 1
  • Jin Cheon Kim
    • 1
  1. 1.Department of SurgeryUniversity of Ulsan College of Medicine and Asan Medical CenterSeoulRepublic of Korea