, Volume 25, Issue 3, pp 313-321
Date: 24 Dec 2009

XRCC1 polymorphisms and risk of colorectal cancer: a meta-analysis

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Abstract

Purpose

Previous studies investigating the association between X-ray repair cross-complementation group 1 (XRCC1) polymorphisms and colorectal cancer (CRC) risk has provided inconsistent results. The aim of our study was to clarify the effects of XRCC1variants on CRC risk.

Materials and methods

We conducted searches of the published literature in PubMed, Embase, and CBM databases up to July 6, 2009. Meta-analysis was performed by critically reviewing 14 studies with a total of 2,776 CRC cases and 4,402 controls on Arg399Gln polymorphism, four studies with a total of 931 CRC cases and 1,547 controls on Arg280His polymorphism, and nine studies with a total of 1,709 CRC cases and 3,233 controls on Arg194Trp polymorphism, respectively. Statistical analysis was performed with the software programs Review Manager (version 5.0.10) and STATA (version 9.2).

Results

No significant association between Arg399Gln polymorphism and CRC risk was observed in both total population analyses and subgroup analyses based on ethnicity (ORCo-dominant model = 1.04, 95% CI 0.74–1.45, P OR = 0.82; ORDominant model = 1.02, 95% CI 0.80–1.30, P OR = 0.88; OR Recessive model = 1.04, 95% CI 0.81–1.34, P OR = 0.78). Arg280His polymorphism also had no significant association with CRC risk (ORCo-dominant model = 0.85, 95% CI 0.32–2.31, P OR = 0.76; ORDominant model = 1.11, 95% CI 0.87–1.40, P OR = 0.40; ORRecessive model = 0.85, 95% CI 0.32–2.31, P OR = 0.75). Besides, there was also no evidence of association between Arg194Trp polymorphism and CRC risk (ORCo-dominant model = 1.43, 95% CI 0.83–2.48, P OR = 0.20; ORDominant model = 1.14, 95% CI 0.87–1.51, P OR = 0.34; ORRecessive model = 1.32, 95% CI 0.82–2.13, P OR = 0.25).

Conclusions

No association is found between the polymorphisms in XRCC1 (Arg399Gln, Arg280His, and Arg194Trp) and risk of colorectal cancer.