International Journal of Colorectal Disease

, Volume 25, Issue 3, pp 313–321

XRCC1 polymorphisms and risk of colorectal cancer: a meta-analysis

  • Bin Wang
  • Dan Wang
  • Gang Huang
  • Chao Zhang
  • Dong-hua Xu
  • Weiping Zhou
Original Article

DOI: 10.1007/s00384-009-0866-0

Cite this article as:
Wang, B., Wang, D., Huang, G. et al. Int J Colorectal Dis (2010) 25: 313. doi:10.1007/s00384-009-0866-0

Abstract

Purpose

Previous studies investigating the association between X-ray repair cross-complementation group 1 (XRCC1) polymorphisms and colorectal cancer (CRC) risk has provided inconsistent results. The aim of our study was to clarify the effects of XRCC1variants on CRC risk.

Materials and methods

We conducted searches of the published literature in PubMed, Embase, and CBM databases up to July 6, 2009. Meta-analysis was performed by critically reviewing 14 studies with a total of 2,776 CRC cases and 4,402 controls on Arg399Gln polymorphism, four studies with a total of 931 CRC cases and 1,547 controls on Arg280His polymorphism, and nine studies with a total of 1,709 CRC cases and 3,233 controls on Arg194Trp polymorphism, respectively. Statistical analysis was performed with the software programs Review Manager (version 5.0.10) and STATA (version 9.2).

Results

No significant association between Arg399Gln polymorphism and CRC risk was observed in both total population analyses and subgroup analyses based on ethnicity (ORCo-dominant model = 1.04, 95% CI 0.74–1.45, POR = 0.82; ORDominant model = 1.02, 95% CI 0.80–1.30, POR = 0.88; OR Recessive model = 1.04, 95% CI 0.81–1.34, POR = 0.78). Arg280His polymorphism also had no significant association with CRC risk (ORCo-dominant model = 0.85, 95% CI 0.32–2.31, POR = 0.76; ORDominant model = 1.11, 95% CI 0.87–1.40, POR = 0.40; ORRecessive model = 0.85, 95% CI 0.32–2.31, POR = 0.75). Besides, there was also no evidence of association between Arg194Trp polymorphism and CRC risk (ORCo-dominant model = 1.43, 95% CI 0.83–2.48, POR = 0.20; ORDominant model = 1.14, 95% CI 0.87–1.51, POR = 0.34; ORRecessive model = 1.32, 95% CI 0.82–2.13, POR = 0.25).

Conclusions

No association is found between the polymorphisms in XRCC1 (Arg399Gln, Arg280His, and Arg194Trp) and risk of colorectal cancer.

Keywords

Colorectal cancerGene polymorphismX-ray repair cross-complementation group 1Single nucleotide polymorphismMeta-analysis

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Bin Wang
    • 1
    • 5
  • Dan Wang
    • 2
  • Gang Huang
    • 3
  • Chao Zhang
    • 1
    • 5
  • Dong-hua Xu
    • 4
  • Weiping Zhou
    • 3
  1. 1.Department of Intern Team, Changhai HospitalThe Second Military Medical UniversityShanghaiChina
  2. 2.Department of LibraryHebei Medical UniversityShijiazhuangChina
  3. 3.The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghaiChina
  4. 4.Department of ImmunologyNanjing Medical UniversityNanjingChina
  5. 5.Department of Graduates Management BrigadeThe Second Military Medical UniversityShanghaiChina