International Journal of Colorectal Disease

, Volume 25, Issue 2, pp 267–275

Efficacy of mechanical bowel preparation with polyethylene glycol in prevention of postoperative complications in elective colorectal surgery: a meta-analysis

  • Qian D. Zhu
  • Qi Y. Zhang
  • Qi Q. Zeng
  • Zheng P. Yu
  • Chong L. Tao
  • Wen J. Yang
Original Article

DOI: 10.1007/s00384-009-0834-8

Cite this article as:
Zhu, Q.D., Zhang, Q.Y., Zeng, Q.Q. et al. Int J Colorectal Dis (2010) 25: 267. doi:10.1007/s00384-009-0834-8

Abstract

Purpose

The aim of this study was to estimate efficacy of mechanical bowel preparation with polyethylene glycol (PEG) in prevention of postoperative complications in elective colorectal surgery.

Method

A literature search of MEDLINE (PubMed), EMBASE, and the Cochrane Library was done to identify randomized controlled trials involving comparison of postoperative complications after mechanical bowel preparation with PEG (PEG group) and no preparation (control group). A meta-analysis was set up to distinguish overall difference between the two groups.

Results

A total of five randomized controlled trials was identified according to our inclusion criteria. The use of PEG for mechanical bowel preparation did not significantly reduce the rate of surgical site infection (SSI; odds ratio (OR) 95% confidence interval (CI), 1.39 (0.85–2.25); P = 0.19) including incisional SSI (OR 95% CI, 1.44 (0.88–2.33); P = 0.15), organ/space SSI (OR 95% CI, 1.10 (0.43–2.78); P = 0.49), anastomotic leak (OR 95% CI,1.78 (0.95–3.33; P = 0.07), mortality (OR 95% CI, 1.24 (0.37–4.14; P = 0.73), infectious complications (OR 95% CI, 1.14 (0.62–2.08); P = 0.67), and hospital stay (weighted mean difference 95% CI, 2.17 (−2.90–7.25); P = 0.40) except main complications (OR 95% CI, 1.76 (1.09–2.85); P = 0.02), of which the rate increased significantly in the PEG group.

Conclusion

The use of mechanical bowel preparation with PEG does not significantly lower postoperative complications in elective colorectal surgery.

Keywords

Polyethylene glycol Mechanical bowel preparation Colorectal surgery Meta-analysis 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Qian D. Zhu
    • 1
  • Qi Y. Zhang
    • 1
  • Qi Q. Zeng
    • 1
  • Zheng P. Yu
    • 1
  • Chong L. Tao
    • 1
  • Wen J. Yang
    • 1
  1. 1.Department of General SurgeryThe First Affiliated Hospital, Wenzhou Medical CollegeWenzhouChina

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