International Journal of Colorectal Disease

, Volume 24, Issue 7, pp 845–850

Prognostic impact of intrahepatic lymphatic and microvascular involvement in cases of colorectal liver metastases

  • Maximilian Bockhorn
  • Georgios Sotiropoulos
  • Jan Neuhaus
  • George Sgourakis
  • Sien-Yi Sheu
  • Ernesto Molmenti
  • Christian Fingas
  • Tanja Trarbach
  • Andreja Frilling
  • Christoph E. Broelsch
Original Article

DOI: 10.1007/s00384-009-0674-6

Cite this article as:
Bockhorn, M., Sotiropoulos, G., Neuhaus, J. et al. Int J Colorectal Dis (2009) 24: 845. doi:10.1007/s00384-009-0674-6

Abstract

Objective

The purpose of this study was to evaluate the effect of intrahepatic microvascular and lymphatic infiltration on survival in cases of colorectal liver metastases.

Materials and methods

Prospectively collected data of 331 patients were analyzed for microvascular invasion (V), lymphatic infiltration (L), and resection margins (R) with respect to overall and disease-free survival.

Results

One-, 3-, and 5-year overall survival rates for R0 resected patients were 89%, 64%, and 39%, respectively. The corresponding survival rates for R1 resected patients were 83%, 42%, and 24% (p < 0.001). The sole presence of microvascular invasion (V1) or lymphatic infiltration (L1) was not associated with a diminished overall survival (p > 0.05). However, patients with a combination of L1V1 had a significantly worse overall survival of 68%, 20%, and 0% when compared to L0V0 patients. This difference was not influenced by the status of the resection margin. No other parameter investigated was found to be of predictive value.

Conclusions

The presence of combined lymphatic and vascular invasion (L1V1) constitutes a predictor of poor overall and disease-free survival. This subgroup of patients might benefit from adjuvant strategies such as chemotherapeutic treatment.

Keywords

Liver metastasesResectionLymphatic vessel infiltrationVascular invasion

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Maximilian Bockhorn
    • 1
  • Georgios Sotiropoulos
    • 1
  • Jan Neuhaus
    • 1
  • George Sgourakis
    • 1
  • Sien-Yi Sheu
    • 2
  • Ernesto Molmenti
    • 1
  • Christian Fingas
    • 1
  • Tanja Trarbach
    • 3
  • Andreja Frilling
    • 1
  • Christoph E. Broelsch
    • 1
  1. 1.Department of General-, Visceral- and Thoracic SurgeryUniversity Hospital Hamburg EppendorfHamburgGermany
  2. 2.Department of Pathology and NeuropathologyUniversity Hospital EssenEssenGermany
  3. 3.Department of OncologyUniversity Hospital EssenEssenGermany