Original Article

International Journal of Colorectal Disease

, Volume 24, Issue 4, pp 419-425

Hepatectomy for liver metastasis of colorectal cancer

  • Jianmin XuAffiliated withDepartment of General Surgery, Zhongshan Hospital, Fudan UniversityColorectal Cancer Research Center, Fudan UniversityDepartment of Surgery, Shanghai Medical College, Fudan University Email author 
  • , Ye WeiAffiliated withDepartment of General Surgery, Zhongshan Hospital, Fudan UniversityColorectal Cancer Research Center, Fudan UniversityDepartment of Surgery, Shanghai Medical College, Fudan University
  • , Yunshi ZhongAffiliated withDepartment of General Surgery, Zhongshan Hospital, Fudan UniversityColorectal Cancer Research Center, Fudan UniversityDepartment of Surgery, Shanghai Medical College, Fudan University
  • , Jia FanAffiliated withDepartment of Hepatic Surgery, Zhongshan Hospital, Fudan University
  • , Jian ZhouAffiliated withDepartment of Hepatic Surgery, Zhongshan Hospital, Fudan University
  • , Lunxiu QinAffiliated withDepartment of Hepatic Surgery, Zhongshan Hospital, Fudan University
  • , Li RenAffiliated withDepartment of General Surgery, Zhongshan Hospital, Fudan UniversityColorectal Cancer Research Center, Fudan UniversityDepartment of Surgery, Shanghai Medical College, Fudan University
  • , Xinyu QinAffiliated withDepartment of General Surgery, Zhongshan Hospital, Fudan UniversityColorectal Cancer Research Center, Fudan UniversityDepartment of Surgery, Shanghai Medical College, Fudan University

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Abstract

Objective

The objective of this study was to investigate whether hepatic resection (HR) can increase the survival of liver metastasis of colorectal cancer (CRC).

Materials and methods

CRC patients (n = 669) with liver metastasis treated at the Zhongshan Hospital, Fudan University from 1/2000 to 7/2007 were included in the study to investigate the relationship between HR and cancer survival.

Results

CRC patients (n = 669) with liver metastases who had primary tumor resection were grouped in synchronous liver metastasis (SLM; 56.7%, n = 379) and metachronous liver metastasis (MLM) groups (43.3%, n = 290). Hepatic resection rates were lower (32.5%, n = 123) in the SLM than the MLM group (44.8%, n = 130, P < 0.05). The 30-day mortality rate in the MLM (2.3%) was significantly lower than SLM (2.4%) groups. The 5-year survival rates (36.6%) was same compared to SLM group (33.1%, P > 0.05). One-, 2-, and 3-year survival of stages I and II operation cases were 92.5% vs 86.5%, 0.7% vs 58.0%, and 42.1% vs 44.9% (P > 0.05) in the SLM group, respectively. Recurrence after first hepatic resection associated with a 2.23-fold increased risk of death (P < 0.01). Incision margins larger than 1 cm and HR for recurrence associated with 34% and 27% (P < 0.05) decreased death risk.

Conclusions

Hepatic resection could help the survival of liver metastasis of colorectal cancer, and stage I surgery is safe for this disease.

Keywords

Colorectal neoplasms Liver Neoplasm metastasis Hepatectomy