International Journal of Colorectal Disease

, 23:757

Mucinous colorectal adenocarcinoma: influence of mucin expression (Muc1, 2 and 5) on clinico-pathological features and prognosis

  • Rodrigo Oliva Perez
  • Bárbara Helou Bresciani
  • Cláudio Bresciani
  • Igor Proscurshim
  • Desiderio Kiss
  • Joaquim Gama-Rodrigues
  • Diego Daniel Pereira
  • Viviane Rawet
  • Ivan Cecconnello
  • Angelita Habr-Gama
Original Article

DOI: 10.1007/s00384-008-0486-0

Cite this article as:
Perez, R.O., Bresciani, B.H., Bresciani, C. et al. Int J Colorectal Dis (2008) 23: 757. doi:10.1007/s00384-008-0486-0
  • 131 Downloads

Abstract

Background

Mucinous component is associated with distinct clinical and pathological features and poor survival in colorectal cancer. The purpose of this study was to determine differences in outcomes of patients with mucinous colorectal adenocarcinoma according to the type of mucin expressed.

Materials and Methods

Immunohistochemistry was performed in all tumors of patients who underwent radical surgery between 1998 and 2003 with mucinous colorectal cancer using antibodies against MUC1, 2, and 5. Correlation between immunoexpression and clinical, pathological features and survival was performed.

Results

Of the 418 patients treated in this period, only 35 had a mucinous adenocarcinoma. Of these, 25 were positive for 1 or more mucin expression. MUC2 expression correlated with tumor site and depth of penetration, while MUC5 expression correlated to tumor site. Overall survival was significantly worse for patients with MUC2 expression, and disease-free survival was significantly worse for patients with MUC1 expression.

Conclusions

Mucin expression may have significant correlation to specific clinical-pathological features and survival of patients with mucinous-type colorectal adenocarcinoma. These differences may reflect distinct molecular mechanisms involved in carcinogenesis of mucinous colorectal adenocarcinoma.

Keywords

Rectal cancerMucinous adenocarcinomaMucinsImmunohistochemistry

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Rodrigo Oliva Perez
    • 1
  • Bárbara Helou Bresciani
    • 1
  • Cláudio Bresciani
    • 1
  • Igor Proscurshim
    • 1
  • Desiderio Kiss
    • 1
  • Joaquim Gama-Rodrigues
    • 1
  • Diego Daniel Pereira
    • 1
  • Viviane Rawet
    • 2
  • Ivan Cecconnello
    • 1
  • Angelita Habr-Gama
    • 1
  1. 1.Department of GastroenterologyUniversity of São Paulo School of MedicineSão PauloBrazil
  2. 2.Department of PathologyUniversity of São Paulo School of MedicineSão PauloBrazil