International Journal of Colorectal Disease

, Volume 18, Issue 5, pp 451–454

Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy

Authors

    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Mariano García-Arranz
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Lourdes Gómez García
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Eduardo Serna Cuellar
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Ignacio Fernández Blanco
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Luis Asensio Prianes
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • José Antonio Rodríguez Montes
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Francisca Lima Pinto
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Dolores Herreros Marcos
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
  • Luis García-Sancho
    • Department of General Surgery, La Paz University HospitalAutonomous University of Madrid
Case Report

DOI: 10.1007/s00384-003-0490-3

Cite this article as:
García-Olmo, D., García-Arranz, M., García, L.G. et al. Int J Colorectal Dis (2003) 18: 451. doi:10.1007/s00384-003-0490-3
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Abstract

Background and aims

Rectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle.

Patient and methods

We report here the case of a young patient with Crohn's disease who had a recurrent rectovaginal fistula that was treated by autologous stem-cell transplantation with a lipoaspirate as the source of stem cells.

Results

Although Crohn's disease is the worst condition for a surgical approach in cases of rectovaginal fistula, we observed good closure. Since the surgical procedure 3 month ago the patient has not experienced vaginal flatus or fecal incontinence through her vagina. Thus our treatment seems to be effective.

Conclusion

Cell transplantation to overcome healing problems is a new surgical tool, and careful evaluation of this new modality may provide an opportunity to define a new era in the treatment of surgical challenges associated with healing disorders. Ethical and safety items do not seem to be critical problems using autologous stem cells.

Keywords

Stem cellsAutologous stem cellsStem-cells transplantationRectovaginal fistulaPerianal Crohn's disease

Copyright information

© Springer-Verlag 2003