Pediatric Surgery International

, Volume 24, Issue 7, pp 779–783

Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction

  • Katy Irani
  • Leonel Rodriguez
  • Daniel P. Doody
  • Allan M. Goldstein
Original Article

DOI: 10.1007/s00383-008-2171-3

Cite this article as:
Irani, K., Rodriguez, L., Doody, D.P. et al. Pediatr Surg Int (2008) 24: 779. doi:10.1007/s00383-008-2171-3

Abstract

Internal anal sphincter (IAS) dysfunction is a cause of refractory constipation in children. The goal of this study was to determine whether intrasphincteric injection of botulinum toxin is effective in the treatment of constipation in pediatric patients with IAS dysfunction. A retrospective review was performed of 24 pediatric patients with intractable constipation. All patients had abnormal anorectal manometry, with either elevated IAS resting pressure (≥100 mm Hg) or an absent or diminished rectoanal inhibitory reflex. Patients with Hirschsprung’s disease were excluded. All patients underwent botox injection into the IAS and were followed for a minimum of 6 months. Of 24 patients, 22 experienced significant improvement in their constipation lasting greater than 2 weeks. The duration of effect was variable, with 12 patients demonstrating benefit lasting at least 6 months. Transient postoperative incontinence occurred in five patients. Intrasphincteric injection of botox is a safe and effective treatment for intractable constipation in children with IAS dysfunction.

Keywords

ConstipationAnal achalasiaInternal anal sphincterBotulinum toxinAnorectal manometry

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Katy Irani
    • 1
    • 2
  • Leonel Rodriguez
    • 3
  • Daniel P. Doody
    • 1
  • Allan M. Goldstein
    • 1
  1. 1.Department of Pediatric Surgery, Pediatric Intestinal Rehabilitation ProgramMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Department of SurgeryNew York UniversityNew YorkUSA
  3. 3.Division of Pediatric Gastroenterology, Pediatric Intestinal Rehabilitation ProgramMassachusetts General Hospital, Harvard Medical SchoolBostonUSA