Review Article

Pediatric Surgery International

, Volume 24, Issue 7, pp 755-761

Open Access This content is freely available online to anyone, anywhere at any time.

Congenital diaphragmatic hernia and retinoids: searching for an etiology

  • Sandra MontedonicoAffiliated withThe Children’s Research Centre, Our Lady’s Children’s HospitalCentro de Investigación en Biología de la Reproducción, Escuela de Medicina, Universidad de Valparaíso
  • , Nana NakazawaAffiliated withThe Children’s Research Centre, Our Lady’s Children’s Hospital
  • , Prem PuriAffiliated withThe Children’s Research Centre, Our Lady’s Children’s Hospital Email author 

Abstract

Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH.

Keywords

Congenital diaphragmatic hernia (CDH) Retinoids Nitrofen