Pediatric Surgery International

, Volume 24, Issue 4, pp 499–502

Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases

  • A. Crocoli
  • S. Madafferi
  • A. Jenkner
  • A. Zaccara
  • A. Inserra
Case Report

DOI: 10.1007/s00383-007-2067-7

Cite this article as:
Crocoli, A., Madafferi, S., Jenkner, A. et al. Pediatr Surg Int (2008) 24: 499. doi:10.1007/s00383-007-2067-7

Abstract

Alpha-fetoprotein (AFP) is a common tumoral marker in pediatric neoplasms; increased serum levels are usually encountered in tumors arising from tissues producing AFP during fetal life. However, elevation of such protein is rarely found in patients with Wilms tumor (WT). Three patients with WT and elevated serum AFP were studied over the course of the disease. One patient had left WT with invasion of aorto-caval lymph nodes and lung metastases. The second patient was referred to our center for abdominal recurrence of bilateral WT whereas the third showed right WT with inferior vena cava thrombosis. AFP levels demonstrated a trend parallel to decrease/increase of tumor size, with further elevation in patients with metastases. Elevated AFP serum levels in patients with WT could be related to peculiar histological features and serial dosage might be a useful diagnostic and prognostic test.

Keywords

Wilms tumor Alpha-fetoprotein Serum levels Children 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • A. Crocoli
    • 1
  • S. Madafferi
    • 1
  • A. Jenkner
    • 2
  • A. Zaccara
    • 3
  • A. Inserra
    • 1
  1. 1.Operative Unit of General and Thoracic SurgeryBambino Gesù Children HospitalRomeItaly
  2. 2.Operative Unit of OncologyBambino Gesù Children HospitalRomeItaly
  3. 3.Operative Unit of Urodynamics and Nephro-UrologyBambino Gesù Children HospitalRomeItaly