Pediatric Surgery International

, Volume 23, Issue 3, pp 205–209

Atypical congenital mesoblastic nephroma presenting in the perinatal period

Original Article

DOI: 10.1007/s00383-006-1831-4

Cite this article as:
Jones, V.S. & Cohen, R.C. Pediatr Surg Int (2007) 23: 205. doi:10.1007/s00383-006-1831-4

Abstract

Congenital mesoblastic nephroma (CMN) is a rare tumour of infancy having an overall good prognosis. The less common, atypical CMNs have cellular elements in them and tend to have an unpredictable course. Occurrence in the perinatal period may further change the outcome. By reporting three patients presenting in the perinatal period with atypical CMN, an attempt is made in this paper to characterize the clinical behaviour of these variant tumours. Though one of our patients had an uneventful course, the other two had several complications including polyhydramnios, prematurity, hypertension, haemodynamic instability and tumour spillage. The course was complicated by recurrence in the latter two and refractoriness to chemotherapy and death in one. That the atypical subset of CMNs occurring in the perinatal period can have a stormy course is well illustrated by this report. Possible prognostic factors are evaluated and the sparse reports of similar cases in the literature are reviewed and compared.

Keywords

Congenital mesoblastic nephroma Atypical variant Perinatal period 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Paediatric surgeryThe Children’s Hospital at WestmeadSydneyAustralia

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