Pediatric Surgery International

, Volume 22, Issue 5, pp 462–464

Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology

Case Report

DOI: 10.1007/s00383-006-1636-5

Cite this article as:
Towu, E. & Stanton, M. Ped Surgery Int (2006) 22: 462. doi:10.1007/s00383-006-1636-5

Abstract

Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.

Keywords

GISTGastrointestinal bleed

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Paediatric SurgeryLewisham University Hospital NHS TrustLondonUK
  2. 2.Southampton General HospitalSouthampton University NHS TrustSouthamptonUK