Pediatric Surgery International

, Volume 22, Issue 5, pp 462–464

Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology

Case Report

DOI: 10.1007/s00383-006-1636-5

Cite this article as:
Towu, E. & Stanton, M. Ped Surgery Int (2006) 22: 462. doi:10.1007/s00383-006-1636-5


Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.


GISTGastrointestinal bleed

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Paediatric SurgeryLewisham University Hospital NHS TrustLondonUK
  2. 2.Southampton General HospitalSouthampton University NHS TrustSouthamptonUK