Child's Nervous System

, Volume 29, Issue 11, pp 2057–2064

Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas

Authors

  • Michael Safaee
    • Department of Neurological SurgeryUniversity of California San Francisco
  • Michael C. Oh
    • Department of Neurological SurgeryUniversity of California San Francisco
  • Joseph M. Kim
    • Department of Neurological SurgeryUniversity of California San Francisco
  • Derick Aranda
    • Department of Neurological SurgeryUniversity of California San Francisco
  • Phiroz E. Tarapore
    • Department of Neurological SurgeryUniversity of California San Francisco
  • Tene A. Cage
    • Department of Neurological SurgeryUniversity of California San Francisco
  • Nalin Gupta
    • Department of Neurological SurgeryUniversity of California San Francisco
    • Department of PediatricsUniversity of California San Francisco
    • Department of Neurological SurgeryUniversity of California San Francisco
Original Paper

DOI: 10.1007/s00381-013-2149-x

Cite this article as:
Safaee, M., Oh, M.C., Kim, J.M. et al. Childs Nerv Syst (2013) 29: 2057. doi:10.1007/s00381-013-2149-x

Abstract

Purpose

Prognostic factors affecting outcomes in pediatric spinal cord ependymomas are limited. We sought to investigate potential associations between extent of resection and histologic grade on progression-free survival (PFS) and overall survival (OS).

Methods

A comprehensive literature search was performed to identify pediatric patients who underwent surgical resection for spinal cord ependymomas. Only manuscripts with clearly defined age, tumor grade, extent of resection, and clinical follow-up were included.

Results

A total of 80 patients were identified with a histologic distribution as follows: 36 % myxopapillary (grade I), 54 % classical (grade II), and 10 % anaplastic (grade III). There was no association between tumor grade and PFS. The only factor associated with improved PFS was gross total resection (GTR), which remained significant in a multivariate model (hazard ratio (HR) = 0.248, p = 0.022). Moreover, older age (HR = 0.818, p = 0.026), GTR (HR = 0.042, p = 0.013), and anaplastic grade (HR = 19.847, p = 0.008) demonstrated a significant association with OS in a multivariate model.

Conclusions

Among pediatric patients with spinal cord ependymomas, PFS did not differ across histologic grades but was prolonged among patients who underwent GTR. Age, extent of resection, and tumor grade were all significantly associated with survival.

Keywords

EpendymomaSpinePediatricHistologic gradeRecurrenceSurvival

Copyright information

© Springer-Verlag Berlin Heidelberg 2013