Child's Nervous System

, Volume 29, Issue 4, pp 583–588

Pediatric diffuse intrinsic pontine glioma patients from a single center

Authors

    • Pediatric Hematology–Oncology, Cerrahpasa Medical Faculty and Oncology InstituteIstanbul University
    • Pediatric Hematology–Oncology, Oncology InstituteIstanbul University
  • Fatma Betul Cakir
    • Department of Pediatric Hematology and Oncology, School of MedicineBezmialem Vakif University
    • Department of Radiation Oncology, Oncology InstituteIstanbul University
  • Omer Gorgun
    • Pediatric Hematology–Oncology, Cerrahpasa Medical Faculty and Oncology InstituteIstanbul University
    • Pediatric Hematology–Oncology, Oncology InstituteIstanbul University
  • Inci Ayan
    • Pediatric Hematology–Oncology, Oncology InstituteIstanbul University
  • Emin Darendeliler
    • Department of Radiation Oncology, Oncology InstituteIstanbul University
Original Paper

DOI: 10.1007/s00381-012-1986-3

Cite this article as:
Kebudi, R., Cakir, F.B., Agaoglu, F.Y. et al. Childs Nerv Syst (2013) 29: 583. doi:10.1007/s00381-012-1986-3

Abstract

Background

The prognosis of children with diffuse intrinsic pontine gliomas (DIPG) is dismal. This study aims to evaluate the characteristics and treatment outcome of children with DIPG in a single center.

Methods

We reviewed the outcome of children with DIPG treated at the Oncology Institute of Istanbul University from February 1999 to May 2012.

Results

Fifty children (26 female, 24 male) with the median age of 7 years were analyzed. The median duration of symptoms was 30 days. All patients received radiotherapy (RT). Before the year 2000, 12 patients received only RT. Thirty-eight had concomitant and/or adjuvant chemotherapy with RT. Between 2000 and 2004, 17 patients received cis-platinum or vincristine as sensitizers during RT and CCNU + vincristine combination after RT. Since 2004, 21 patients received temozolomide (TMZ) concomitantly during RT and as adjuvant chemotherapy after RT. The median survival time of all patients was 13 months (1–160 months). Patients receiving RT + TMZ had a significantly higher overall survival than patients with only RT (p = 0.018). Patients receiving RT + chemotherapy other than TMZ also had a significantly higher overall survival than patients receiving only RT (p = 0.013). Patients receiving RT + TMZ + and chemotherapy other than TMZ had a significantly higher survival than patients receiving only RT (p = 0.005).

Conclusion

In our series, patients receiving RT + TMZ and also patients receiving RT + chemotherapy other than TMZ had a significantly higher overall survival than patients treated with only RT. Hence, administering chemotherapy during and after RT seems to prolong survival in some DIPG patients.

Keywords

Diffuse pontine gliomaPediatricRadiotherapyTemozolomide

Copyright information

© Springer-Verlag Berlin Heidelberg 2012