Child's Nervous System

, Volume 27, Issue 8, pp 1307–1316

Chemical priming for spinal cord injury: a review of the literature part II—potential therapeutics


  • Martin M. Mortazavi
    • Department of NeurosurgeryBarrow Neurological Institute
  • Ketan Verma
    • Pediatric NeurosurgeryChildren’s Hospital
  • Aman Deep
    • Pediatric NeurosurgeryChildren’s Hospital
  • Fatemeh B. Esfahani
    • Pediatric NeurosurgeryChildren’s Hospital
  • Patrick R. Pritchard
    • Division of Neurosurgery
    • Pediatric NeurosurgeryChildren’s Hospital
  • Nicholas Theodore
    • Department of NeurosurgeryBarrow Neurological Institute
Original Paper

DOI: 10.1007/s00381-010-1365-x

Cite this article as:
Mortazavi, M.M., Verma, K., Deep, A. et al. Childs Nerv Syst (2011) 27: 1307. doi:10.1007/s00381-010-1365-x



Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of “arousal” towards better function. Priming can be mechanical as trauma is known to enhance activity in cells.

Materials and methods

A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries.


Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI.


Spinal cordInjuryExperimentalTraumaTreatment

Copyright information

© Springer-Verlag 2010