The bishop and anatomist Niels Stensen (1638–1686) and his contributions to our early understanding of the brain
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- Tubbs, R.S., Mortazavi, M.M., Shoja, M.M. et al. Childs Nerv Syst (2011) 27: 1. doi:10.1007/s00381-010-1236-5
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Many physicians are familiar with the parotid duct and the Danish physician/anatomist's name associated with it. However, most are unaware of Niels Stensen's life and his significant contributions to the early study of the brain. This physician of the Medici court was clearly ahead of his time and found errors in the publications of such giants as Varolius and Willis. The present review discusses the life of this seventeenth century anatomist, physician, and priest/bishop and highlights his contributions to neuroanatomy.
“Fair is what we see, Fairer what we have perceived, Fairest what is still in veil.”
After brief visits to Paris and Montpelier, Stensen moved to Florence, Italy in 1665–1666. In Italy, Grand Duke Ferdinand II of the Medici palace appointed Stensen to a hospital post that left him time for research . Later, he was elected to the Academia del Cimento (Experimental Academy), a body of researchers inspired by Galileo's experimental and mathematical approaches to science. Stensen traveled through Europe visiting France, Germany, and the Netherlands. In Leiden, he met renowned individuals such as Jan Swammerdam, Frederik Ruysch, Reinier de Graaf, François de la Boë Sylvius, and the famous Jewish philosopher Baruch Spinoa . In Montpellier, he met Royal Society members Martin Lister and William Croone, who introduced Stensen's work to this group . While in Rome, he met Alexander VII and Marcello Malpighi, the founder of microscopic anatomy .
“having been allowed to dissect on my own, I succeeded in the first sheep’s head which I purchased and dissected by myself in the study hall on April 7 in finding a duct which—as far as I know—has not previously been described. It was my intention after removing the ordinary outer parts to do a section of the brain when I happened to decide first to examine the vessels running through the mouth. Examining with that intention the course of the veins and arteries, by inserting a probe I observed that the point is no longer enclosed in the narrow sheath but moves freely in a spacious cavity; and pushing the instrument further forward, I at once heard it clink against the teeth themselves .”
Elsewhere in his letter to Bartholin, Stensen referred to his discovery as an inventiuncula—a small observation.
Although the parotid duct was discovered by Stensen, his teacher, Bläes, laid claim to its discovery in 1661. This dispute with Bläes resulted in Stensen enrolling at the University of Leiden on July 27, 1661. It was here that he began compiling his Anatomical Observations, which he published in 1662 and dedicated to his professors in Copenhagen and Leiden, a group that included the mathematician Jakob Golius (1596–1667) who was a student of Galileo's (as was Ferdinando II, the brother to Stensen's Medici benefactor, and Vincenzio Viviani (1622–1703), a future collaborator) . Two years later, Bläes again attempted to convince others that he had discovered the parotid duct; however, this time Stensen publically dismissed his claim in an official publication in 1663.
Although earlier in his career, Stensen's former professor Thomas Bartholin, had referred to him as the “royal anatomist” and the century's “new Democritus,” Bartholin later became envious of Stensen and tried to block his academic ascent by, for example, hiring his own nephew Mathias Jacobsen instead of Stensen . As anatomist, Stensen became well known across Europe by his public demonstrations of anatomical dissections in the Theatrum Anatomicum. In 1664, from the University of Leiden, came the news that due to Stensen's “uncommon learning,” he had been made a doctor of medicine in absentia .
“It would be a great blessing to mankind if this most delicate part, and which is liable to so many dangerous diseases, were as well understood as the generality of anatomists and philosophers imagining it to be…as if they had been present at the formation of this surprising machine, and had been let into all the designs of the Great Architect. We need only view a dissection of the large mass, the brain, to have ground to bewail our ignorance. Let us without flattering ourselves any longer, freely acknowledge our ignorance, that we may not first deceive ourselves and others afterwards, by promising to show them the true structure of this organ” .
“The ancients were so far prepossessed about the ventricles as to take the anterior for the seat of common sense, the posterior for the seat of memory, that the judgment which they said was lodged in the middle, might more easily reflect on the ideas which came from either ventricle. Why should we believe them? Willis lodges common sense in the corpora striata, the imagination in the corpus callosum, and the memory in the cortical substance. How can he then be sure that these three operations are performed in the three bodies which he pitches upon? Who is able to tell us whether the nervous fibers begin in the corpora striata, or if they pass through the corpus callosum all the way to the cortical substance? We know so little of the true structure of the corpus callosum that a man of tolerable genius may say about it, whatever he pleases (Fig. 3)” .
“The supposed connection of this gland (pineal) with the brain by means of arteries is likewise groundless: for the whole basis of the gland adheres to the brain, or rather the substance of the gland is continuous with that of the brain, though the contrary be affirmed by Descartes (Fig. 3). (Moreover), it is not known whether the pituitary gland acts in any respect on the pituita (mucous)” .
Brain in general
“The best figures of the brain are those of Willis; but even these contain a great number of important mistakes, and they want many things to perfect them. I have seen but three figures of Varolius, which express in a wretched manner, the best observations that have ever been published on the brain. The principal reason why a great many anatomists have remained in their mistakes, and why they have gone no greater a length than the ancients in dissection, is because they believe that everything has been already taken notice of, and that there is nothing left for the moderns to do (Fig. 4)” .
In addition to his significant contributions to the field of anatomy, Stensen is also regarded as the Father of Geology, and interestingly, the root of his surname means “rock” . Stensen's work on shark teeth led him to question how one solid could come to reside within another solid. While examining these specimens, Stensen was struck by their resemblance to glossopetrae or “tongue stones” . Ancient authorities, such as the Roman author Pliny the Elder, had suggested that these stones fell from the sky or from the moon and some believed that these structures were serpent tongues turned to stone by St. Paul. Stensen argued that glossopetrae were simply fossilized shark teeth. With such discoveries, Stensen is credited with developing the principles that led to the science of stratigraphy and for establishing the foundation on which Darwin's theory of natural selection would be based . Stensen's writings in this field continue to be used by geologists and paleontologists today.
While in Florence, Stensen began to question his Lutheran upbringing. After intense comparative study, he decided that Catholicism, rather than Lutheranism, was more consistent with his religious views and, therefore, converted to Catholicism on All Souls' Day November 4, 1667 to become one of the leading figures in the Counter-Reformation . Not long after his epiphany, Stensen returned to Florence and was ordained a priest in Florence's Cathedral on Easter Eve 1675 . Despite his accomplishments, Stensen's fellow Dutchman refrained from promoting him to the level of professor at the University of Copenhagen. This resulted in Stensen moving to Florence, where he was cordially received by the Medici and appointed as anatomist at the Santa Maria Nuova hospital . Shortly after Stensen's conversion to Catholicism, a royal letter from the Danish king Frederick III arrived announcing his appointment at Copenhagen University, but while Stensen awaited free religious worship status, the king died . It was, therefore, not until 1672 that Stensen was able to return to Copenhagen. In Denmark he was appointed anatomicus regius since a Catholic could not hold the position of professor . Stensen wrote: “This is the true purpose of anatomy: To lead the audience by the wonderful artwork of the human body to the dignity of the soul and by the admirable structure of both to the knowledge and love of God” .
Stensen went to Rome where he was appointed apostolic vicar of northern missions by Pope Innocent XI on August 21, 1677 and was consecrated titular bishop of Titiopolis in Asia Minor (present day Turkey) on September 19 [2, 3]. Later the same year after being appointed Apostolic Legate for Northern Germany and Scandinavia, he left Rome to minister to the minority Roman Catholic populations in northern Germany, Denmark, and Norway . Stensen worked in Hannover until 1680 when he accepted a position in Münster. As an example of his devotion to his religion, Stensen sold his bishop's ring and cross to help the needy and is said to have dressed like a beggar and ate little, becoming so malnourished that one friend described him as a “living corpse” .
Stensen's piety and virtue have been evaluated with the goal of eventual canonization, and centuries after his death, Danish pilgrims appealed to Pope Pius XI to make Stensen a saint . In 1953, as part of this process his corpse was exhumed and reburied in the Capella Stenoniana, a chapel within San Lorenzo. On October 23, 1988, Stensen was beatified (the first step to becoming a saint) by Pope John Paul II and attained the status and title of Blessed (Blessed Nicolas Steno). His day of celebration in the Catholic Church is November 25 . Stensen's name is remembered by the Steno Museum in Århus, Denmark, craters on Mars and the Moon, the Steno Diabetes Center, a research and teaching hospital in Gentofte, Denmark, and the Istituto Niels Stensen, which was founded in 1964 in Florence, Italy and administered by the Jesuit Order.
Stensen's life was short-lived but full of discovery both academically and spiritually. Although he lives on primarily as the eponym “Stensen's duct,” it is his contributions to neuroanatomy that should perhaps be most remembered. It is on the shoulders of giants such as Niels Stensen that we base our current understanding of the nervous system.